ID A0A0L0D5R5_THETB Unreviewed; 901 AA.
AC A0A0L0D5R5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=C2 domain-containing protein {ECO:0000313|EMBL:KNC47712.1};
GN ORFNames=AMSG_03943 {ECO:0000313|EMBL:KNC47712.1};
OS Thecamonas trahens ATCC 50062.
OC Eukaryota; Apusozoa; Apusomonadida; Apusomonadidae; Thecamonas.
OX NCBI_TaxID=461836 {ECO:0000313|EMBL:KNC47712.1, ECO:0000313|Proteomes:UP000054408};
RN [1] {ECO:0000313|EMBL:KNC47712.1, ECO:0000313|Proteomes:UP000054408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50062 {ECO:0000313|EMBL:KNC47712.1,
RC ECO:0000313|Proteomes:UP000054408};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA Burger G., Gray M.W., Holland P.W.H., King N., Lang F.B.F., Roger A.J.,
RA Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Thecamonas trahens ATCC 50062.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL349448; KNC47712.1; -; Genomic_DNA.
DR RefSeq; XP_013759194.1; XM_013903740.1.
DR AlphaFoldDB; A0A0L0D5R5; -.
DR STRING; 461836.A0A0L0D5R5; -.
DR EnsemblProtists; KNC47712; KNC47712; AMSG_03943.
DR GeneID; 25563510; -.
DR eggNOG; KOG3508; Eukaryota.
DR OrthoDB; 20678at2759; -.
DR Proteomes; UP000054408; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054408};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 514..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 627..803
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 901 AA; 94797 MW; 6097A5591CDDDF0E CRC64;
MALLSQVPSV TATFKFTLTD SLTAVVSNEA TATVTILNNA HATTASYAIV EDTRTRVVLA
GTDDVSAAAL SFRIVQLPAA GTLYFAGTDI PVSAGDMVPV ADAGAVDYQP GADFVGVDIL
KFTATSAVSL AESVPAVASF NVSNVNDAPR PQNARVEFFA LDLNSTFALP VVEVDGDVIT
VSVTAIPQAS IVALSQTASA GGADITAMPT IVTDALRRVV AHAVAPTQSS TQGYAAEITF
TAVDPYGLVG TPAVVTVFVK HSFFAANVTA TTAEDTPTTV SLATQDYFGR AYAVYLRSLP
DPATVGTLRL VGSTEAITQA QLPLVLTPAT AGTAVTLIEF VPARDAVVPL TSFEYEIRDT
EGRGEVVVGT VFVSTTAVPD PPRVELTNPS ETLEIADGAV LEITTLVVAE VDDPNAIVSV
NVTAVGTGLV AGSGPLDSVT FAKTLTLSGT SAEIAAQLLA PLRFKSGPEQ RVREATAFEV
QVSAQAQGEE SKLSLFVNVL PVPDPSGVSL DGSLVAAVAA AACTALLFGA VGAFILYRRQ
ESEPKLPPPP QFTPFIYDEN RLVSSAEATG VRAPVSMTTE FTELVVARGQ GLVYALFEVS
AEADIDDVCE RLVFVYEGHG RASAPDLVAC IAQREIQMAA SSVTLFRSNS RACKLYSVYA
KVVGLPYLYA TLGPLFVQLV EQDGSIEVAP EKVRKSKSGS VDVTVNKWRL LVVAQKFFKA
ITESVDAVPY ELRQLAQTLW HEMGKPSAFP ERRSIALGTF FFIRFICPAI AQPEAYGLVR
EVPSSDLRRL LVLVAKTLQN LANGTMFVEK ELDAMNVFID SNQEKMGNFL AAVAGTGGGA
VGTGVPVPAP VYDASVAWLY AHTQALHADL HLLLSGVQVE GARELDQALI RVLPRAPTMS
V
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