ID A0A0L1I6T2_PLAFA Unreviewed; 2775 AA.
AC A0A0L1I6T2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=tRNA/rRNA methyltransferase SpoU type domain-containing protein {ECO:0000259|Pfam:PF00588};
GN ORFNames=PFMG_01531 {ECO:0000313|EMBL:KNG75324.1};
OS Plasmodium falciparum IGH-CR14.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG75324.1, ECO:0000313|Proteomes:UP000054562};
RN [1] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG665046; KNG75324.1; -; Genomic_DNA.
DR EnsemblProtists; KNG75324; KNG75324; PFMG_01531.
DR Proteomes; UP000054562; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0016423; F:tRNA (guanine) methyltransferase activity; IEA:InterPro.
DR GO; GO:0030488; P:tRNA methylation; IEA:InterPro.
DR CDD; cd18091; SpoU-like_TRM3-like; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR045330; Trm3/TARBP1.
DR InterPro; IPR044748; Trm3/TARBP1_C.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR12029:SF11; METHYLTRANSFERASE TARBP1-RELATED; 1.
DR PANTHER; PTHR12029; RNA METHYLTRANSFERASE; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054562}.
FT DOMAIN 2627..2768
FT /note="tRNA/rRNA methyltransferase SpoU type"
FT /evidence="ECO:0000259|Pfam:PF00588"
FT REGION 1617..1684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2134..2155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2427..2550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1617..1661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1662..1684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2775 AA; 332419 MW; EA47D8952901362B CRC64;
MNSVDVLNLL VNFSNSNNIK EYDDELTRNF FSHIMLLLIK DEDKYELCKD VNNYLFDEVI
KKEEEYKGDI KNVKMNDGKK KKKECDKKND GKYGNNLEII ILFIDCLFKK CWNESFFNNN
NNNIDISWVY KLFQLKGGEK NKYSRILLNL LKNILIKIQE ENPDFSIIIF LLKHIQIKIQ
NHIKENQDKN MYLFYEKWKN KLTELSSKGL YMYSYKHLLD NIYVKNQVLS ECNEDEKKNI
IYNNNNDDNN INHNNSEGIN NIILTNKQKR YKNLLSTFDL NFEHLCALFV LYLEEVNGNQ
NYKTSTFQNE VVGLLKNEIS KEHKINIDYD DESIIMELIN YILYHIILIN DKDMRNILIK
DFSFAVKEYI YPTHVFTNVC LNIIDLMYFF LTNDMLEKNM VNGNVPIIKT DKMRNGNHNN
INNNVDMKKD DNVEETIQSN DKKKVFIYNN ENECILDIYY KYMINMYNTD INIDEYLLND
IYNFIILYID YIYNEEFVKN GHINDIRYYF LLFNKGYMDE NVLKKLLYIF NTLINICRKT
TTKNGNNEMS LFIKVWEHFE CIVRCIENFS VHLLKSNWFK IVELINIVSS IKVMYEKKYE
GDKNISDVYD EYNKDTYIHR NHFGKNIEKD IDNNYINTII HNNEKILFFD YLDFYIFQTC
VKRSYNKMNT YMMKDKKMRK EKNDMSSEIN FVIYIDYIIL KLNEYLIWLL ILHKNDSVIR
YSLCGLLDYE NKKNLEISKI LSNETNAIKY TDDPLLCNDK KESDEKKIHI LTFINSICDH
FLFNIFFMHI VKPTLFIKGD MLYYESRIKN FIMSKILYKH KYAYNYLFKF IISLGNINYF
YINLRIILET LLQSINIHNN NNNNNNNIYH HTFNNIFTFY NMIIMNNENT QTYQNYLYKL
NKENINKNYF NTFYYPYNIY YNQNIHSIII NIIKNVKNIS FSRRNNILFI ILEIIIKMND
ALNIFTNIKN YCIFLNLFED SFFIEHLNIF QDILSINENH FLKDILRLKE QKNQINNDLI
NKTYNIYNNE HTDQCNDVIR YQETSGKITK FLFIENRKKE LLYNFIDLLN EHIYFNKYIH
YYGYLRLFHL ILINEGQDNK SELREGIIHL IEYYNEKCNM KSNNDDDNNN NNNHYHYNNH
CNNHNDDDNH CTGLISILIC YIIKNNLFYY FNKSCVVKII HNNIKKLKDI IFENNSICNE
DIDTHNNNNN DNNNITSCYK FYKYIESNFL YMDTLEYINI NEQYISSQNL IHYYNSDYPH
KQHRTYRNAD TYVKNKMNHV VYNDDDDNNN YLVNNKLLTY ISRDLENQEW YCCFFNNVKE
LYDTCCDYLL LTRNKDITKY NNNNNDNNNN DNKNGCDNIK LVLVLSFLSN IYNIYNPGKW
DKELNFKIQE LSLKRLHNVK FIHSNKYSLH NYYDKFNYYK YKYFYNCFFC CGSYISLNEE
EMFMFCEKII NDIEICKDEL VYIYLIIKNY MIPYIYTKSN DNMSTSIYNI NQMNEKKMII
FKLLFKQSVI LVDRFSVCKY PIHLLELIFL TLFHPLLIRF EINNFIDKRN YDSHIYNVGE
NDIRENKKEE IYNTKNGIIC TKENFKKDQE SISNDKYCPD ERYQKCCSNI KKEKYTHGDK
KNNDKKDNDK KDNDKKDNDK KNNDKKNNDK KDSDKKNNDN SNDNNNDNNN DNSNDNINDN
NNDDNNIYND DTYLLLNYVR KILENGKTKL SITRNIVIPM LTSFFYNLIN YDDIIYVKKE
YLNNFIELIV DILMYKEYVL LDGKRNFTNE SFKIKKNNNL LLNNFINENI CNYLINKLET
NEEIWFPPEL YEIHHTPIFL RILTLIFLIN LFNILDSTYL SSIKLCTTRE DKYEKVSFNK
KKKMILYIYE TLIIYILKKI DNKNIYHMNN KSPNIINSSN DNKSFFNIQQ NKEKEKIPPL
PSSHGHNIQL RGLQALCMLS KYFKHLKKKK RKEIISYINI ILIYDHLNNT RQYLEYFCLA
ISHSSFVLMY PYLIKYLSHD NVNNQLTITS LIICAYLFLK SKFSYYSFEQ LYINSYAQIC
CTKEKKKKKK SVLTKNGPIL NKKERKLKRR AQGKKVKHII NELVKKNKND INGIVQGVKK
MKNMSTHKND KKGYNDYVTN NNIVHNFDNK KYDNKKYDNK KYDNKKYDNK KYDNKKGKDH
NYNMIKVEMV RRKDSFKNND LKINEDKNGD ICNISNEKKE RRKDNIQNDY FYSEHIFKCL
LKLLYGIVSL CSSHSAIIRS MAQFILYKFI KIKGTSHLNP FFSSLFSYIK YNKDCKRIRK
KIKNQFNYWN VSFFDNIRFL LPTENYSYNH FDEDRNYNNV NTFAHILYNN ELVMSYTFLD
KFKQIVQQEM SFMIFNIDLE KEKQTDKNFK LNSEQNVSLN MINRIYEHNI RTQIERVHDK
EGSSKNVYSD STEETFMSYD NSVDIKSDDV NKKSDSVNKK SDGVNKKSDG VNKKSDGVNK
KSDGVHKKSD DVHKKSDDVH KKGDDVHKKS DDVHKKSDDV HKKGDDVHKK SDDVHKKSDD
IDKKSDDVHK KGDDIDKKSD DIDKKSDDID KKSNIADEHI PINYNEGNKK NITNISSEIN
DDIIILENIL EKNKNNYQKK FDPISNIIEI HNEFRKNYLN NKKKNDLIVI ASLIDKLPNL
AGLCRTCEIF NVKKLLIDNI NIIKDYQFQK ISSTANKWMN IKELKKSNII NYIIKKKKKY
SIIGLEQTHN SQKLNHFVFP KKCILILGDE KEGLPSSILM FLHHCIEIPG QGIIRSLNVH
VSAAITIYEY FKQQL
//
