ID A0A0L1I886_PLAFA Unreviewed; 1064 AA.
AC A0A0L1I886;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=PFMG_01960 {ECO:0000313|EMBL:KNG75702.1};
OS Plasmodium falciparum IGH-CR14.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG75702.1, ECO:0000313|Proteomes:UP000054562};
RN [1] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
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DR EMBL; GG665080; KNG75702.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L1I886; -.
DR EnsemblProtists; KNG75702; KNG75702; PFMG_01960.
DR Proteomes; UP000054562; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 1.10.275.40; -; 2.
DR Gene3D; 1.10.30.20; Bacterial XPD DNA helicase, FeS cluster domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR042493; XPD_DNA_FeS.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KNG75702.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054562}.
FT DOMAIN 8..425
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 535..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1064 AA; 123740 MW; 0ECCD8FD8CDF794C CRC64;
MVVFNLDDVE IFFPYDYIYP EQYAYMKYLK KTLDSEGHCV LEMPTGTGKT VAIFSLITSY
QYHKKDEGKF IFCTRTVAEM EKSLIELKKV IQYRINVMKQ RKVEKLKNEK DDVNDVIKND
DVNDVIKNDD VNDVIKNDDV NDVINNDDEE GANNSLDGSK ENVKEYNKHD DHINNLKEFG
ENSEILAIGI SARRCMCIND KVLLKHEREK IDEECRKLTA TFIREKKYIN NKIDNEIYHP
NVDKISDFIL RNRHHLDIED YFDIYNSRNS LEEYDNIGLC GYYENYKKEF LYDLIKPGVY
TIEDLKVLCK NYKNKENVNV PICPYFCAKK IIEISKVIIL NYQYVIDPKV SKALFSWKDM
NKNVHLKNKN DIIVFDEAHN IDSVCLEALS VNIDRNILNK ASMNITKLMK KIEQSKMLNE
QKLKEECNKI LEKIKLQKCN QSLNVTNNVI NIDNMKCINH MDNINKTRSD GNVGSYLEKE
TNKHHNIEGK PGELFVTNEQ EKKKRKVESS PVAYFDEDMN LMFSDFFLDE SFGDNEKKKK
NHDNNNDINN DDIKNNDDIK NNDDINNDDR NNDDRNNNDD INNNNNDRNN NNGRNNNNED
EDHLNDLCYS PLLMEDIIKN VVIPGNIRKS EHFLNLMRIV VVYLKKYINI YDITSEGPLS
FLYKFEKDTK LDTSFFKYCF DRLKSLLNNL QIVNIEDYSS LNIVCNFCTL LGNYFKGFII
ICEPYPEATG IYDPLIQFAC LDSSIAMKTV INKYKSIILT SGTITPLELY PKLLNFKTVL
TASFPMSFDR NCVCPLIVTK GSDLIPLSSQ FSLRNDLSVI KNYGILLVDM CKCIPDGIVA
YFPSYIYMEQ VISSWYELGV IANILEYKLI FIETKDIVST TIALHNFKKA CDLGKGAVFL
SICRGKIAEG IDFDKHYGKC VILFGIPYQY TLSKILKSRL DFLKETYNIQ ENEFLTFDAM
RQASQCVGRI IRNKKDYGIM IFSDIRYAKH DKKNKLPPWI IKCMDISNIN LTVTTAVDIS
KQFLLNMSQE YRETGQTKIS PLMLKNQVKC WTMVKSILNM DDFI
//