ID A0A0L1I9Y6_PLAFA Unreviewed; 971 AA.
AC A0A0L1I9Y6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=PFMG_02141 {ECO:0000313|EMBL:KNG75948.1};
OS Plasmodium falciparum IGH-CR14.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG75948.1, ECO:0000313|Proteomes:UP000054562};
RN [1] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG665105; KNG75948.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L1I9Y6; -.
DR SMR; A0A0L1I9Y6; -.
DR EnsemblProtists; KNG75948; KNG75948; PFMG_02141.
DR Proteomes; UP000054562; Unassembled WGS sequence.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008045; MCM2.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR Pfam; PF00493; MCM; 2.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01658; MCMPROTEIN2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054562}.
FT DOMAIN 486..716
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..28
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 971 AA; 111496 MW; E5670CA02AA1C208 CRC64;
MEDKKKLEED LESNKYDIDE EDLLEDEGRL NEEERQAELE GESLFEEDEG FIFGADDEKK
EMQKLRNLGL DNDDYDDDFI DDELDYEDNL KARRAAERHM QMQRKQEGKY EKNKFWKTLE
DQLEGDDEEE DIFDKVAEKV AKRRENLHLT AEETDIPDLS NLESAKICLS VNPKDVVFDE
RYQQAADTCF RYFLHKFSLK DSMGLNIDES NTELHEEEHM NSSHQYYIDK IEKMILNDKH
TLIVSAKHLI QFHCENLVQW IEFKPEQILE VLHECLMVEA YRISPKLYKG RICKVVLRDW
PYSTQLRNLR CTELNTLIKV TGVCIKRGYV LPKLRVMYLK CNSCDTTLSE VPIYFADGKK
PVLPRRCPHC QSATFSVDRI KTAYTDYQKI TLQESPCSVP AGRAPRQREV VVTGDLVDKV
KPGEEVEVLG IYKTKYDIGL NIKYGFPILQ TEIEANNIER KEDIQLSELT EDDIKDILKL
SKDPNIRERI ITSIAPAIWG HKDIKTSIAY ALFGGVQKGG DKSFSKNNET NNFGVQNRDI
LNNFKGGHTI RGDINVLLLG DPGLGKSQVL QYVHKTNLRT VYTTGKGASA VGLTAGVRKD
HTTNEWTLEG GALVLADEGI CIIDEFDKMT DKDRVSIHEA MEQQSISISK AGIVTTLRAR
CAVIAAANPI YGRYDPSLTF KENVDLSDPI LSRFDLITVL RDIPNVDEDF YLAEYVVTNH
QLSHPKLENT QNYQKRIENL KNVIVSSSAY EPIPQDLLQK YIIYARTNCK PSLSDVPYAE
ISAKLSNFYS RVRQKASASG GYPLTLRHIE SIIRIAEANA KMRLSHQIYS KDVDYAIATL
LESYVSCQRF AVAKQLSKEF ARYRALFRGG YEVLRELLRR TVQQMIQRQN LKNASAKDFQ
NDSESGTESE AEILNPNNVF LPLHIFMKTA MQNKFSEYQV VNWMKSKVFN EHYAVIKRDG
VEGIISKKFK V
//
