ID A0A0L1IXB4_ASPNO Unreviewed; 1831 AA.
AC A0A0L1IXB4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN ORFNames=ANOM_008375 {ECO:0000313|EMBL:KNG84045.1};
OS Aspergillus nomiae NRRL 13137.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1509407 {ECO:0000313|EMBL:KNG84045.1, ECO:0000313|Proteomes:UP000037505};
RN [1] {ECO:0000313|EMBL:KNG84045.1, ECO:0000313|Proteomes:UP000037505}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 13137 {ECO:0000313|EMBL:KNG84045.1,
RC ECO:0000313|Proteomes:UP000037505};
RA Moore M.G., Shannon B.M., Brian M.M.;
RT "The Genome of the Aflatoxigenic Filamentous Fungus Aspergillus nomius.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000256|ARBA:ARBA00008251}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNG84045.1}.
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DR EMBL; JNOM01000231; KNG84045.1; -; Genomic_DNA.
DR RefSeq; XP_015404968.1; XM_015553631.1.
DR STRING; 1509407.A0A0L1IXB4; -.
DR GeneID; 26810179; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000037505; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000037505};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 1699..1720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1748..1771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 426..1051
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 1084..1688
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT REGION 69..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1831 AA; 204174 MW; 37810AC195AFB745 CRC64;
MIAGMKLRKA DSFQLAHLSV QVDSRCFYSL PPKIQQKLFS KEERSWFHQT QFEARFFDAA
VEAPYPLEKA SRSWHQRPEI QPSDRNSTTT SQSSTLYFDF SDSDSSSDTD MDDSLYDTSV
GVSSRKPTSA VSRQKAQPLR RSSTFPTAPM NITARNSSSR PSSSQSQAHI PRCSTSSIDP
SAQYYQDPEA RLKLRLYLAS PQNFDEAVEF GFPALNNERI MPVERAPAEI ETMPQTFIGT
FLDDEDTSVP DEQCEKRMHV SQLSYVMQSS RSSPLECLDP RHQPWLLPPR SGNKQYPGSD
REMTLKMTLT RPDLRTTVPP PKVDPLKLPL EDSASHLWGS SEDEQGLMRK MWHSAYSSST
TRFFLPPASS KRHRSTSSSP KHNLLSCLLL ALIAQRGAAK PSLPKIAPPT KIAHKPSSLF
YFEDTDIVLM NTVNGDLLRS VDAGETWSVV EGSDGGMKHH VLLIRQHPYD NKKAYALGPS
GRHWVTTDQA KTWESFNIAE FPAIRHYPLV FHGGDSSKVI FQGEECAGRY CIVRSYYTTD
DFATVKLLRE STGGCAWAVG HPQFAEDLNL ADEIKDRSLC VVSGLKVPLP HANRLVYSDD
YFRSNAEGTE TKLREGRPVS GVISTAAVKK FIVAAAKSKG TEELALYVSV DAKTWHRAEF
DGHRIEEDAY TMLESTNYSL QVDVLTSPRS GMGVLFTSNS NGTYFTRNIE HTNRNSEGMV
DFEKIAGIQG IVLVNTVQNP KEVESGSAKK KIISRISFDD GRTFQPLKAD GENLHLHSVT
ALTNIGRVFS SPAPGLVMGI GNTGNHLQDY AECNLYISDD AGVTWRRAIK HPHKYEFGDQ
GAVVIAVRDE GKVDKINYSL DHGKEWASVE LQHKIYPTMV TTTPDSTSLK FIVVGSLKED
KDGEYVIYSI DFDGLHERKC DEEDFEKWPA RLGEDGEPDC LMGHKQFYRR RRANANCFVD
EEFKDPEPIF EACKCTAEDF ECEYRRTEDG KGCVPPSPLS PPEGECKTPD DKFMGPSGWR
LIPGNACIRD GGENLDKEIE RSCKDAGGPS NDGKIGVTLQ LFEARDYAQY YYLERQSSSS
GSDETIIMLN SEQEVYVTHD HGKTWERPLK GEKIARVYLH PYSSDVAFLL TDGKEGFWTE
DRGHTFKPFQ APAPPTQDRF LQTMAFHPVH KDRLIWTGAV GCHSGDCHSD AFIKKGHGKN
WEALLSYVQK CEFESRETRP NSSNLIYCER FEKQSKNGRL QLLSSDEFFN DNEVKFVDVI
NYATMSEFII VASRQPENPD SLVASTSVDG RTFATAQFPP NVQVPVQTAY TVLESSTHAV
FLHVTASSTE GAEYGPIIKS NSNGTSYVLS IDAVNRNSLG YVDFEKMQGL EGVAVVNVVS
NVAEVSKKAP KKLKTMITHN DGAQWMLLPP PAKDADGKSF GCSVETGKGT DDCSLHLHGY
TERKDERDTF ASGSAIGLMM AVGNVGDHLA GGDEADTFIT VDGGISWNLD EGDTWEEFQF
SDVEVRINDI STLPSDTSKN FLLWARVSNS EVQDKFATFN IDFSGIRPRP CLLDEHQGDN
DDYYIWEPKH PFQENNCLFG HSEQYHRKKP SAQCWNDWRE SHVHSIGTNC TCTRADYECD
YNYEPQSDGS CALVPGLPKP DAVEVCKKDP DTIEYWEPTG YRRIPQTTCQ GGLNLDHFVS
KPCPNKEEEY KQKHGISGVG LFFAIVTPLA AAGAAGYYAY SRWDGKFGQI RLGEDAGTSR
SFLSRDSLFV TVPIAIVAGI VAVASALPLL VTSLWRSASG FIRLGRGRGY SRPYASRGSF
AARRGDYTSV VDDEDELLGV EDAELDEDDE A
//
