ID A0A0L1J0Q4_ASPNO Unreviewed; 737 AA.
AC A0A0L1J0Q4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=DNA mismatch repair protein Mlh1 {ECO:0000313|EMBL:KNG85344.1};
GN ORFNames=ANOM_006323 {ECO:0000313|EMBL:KNG85344.1};
OS Aspergillus nomiae NRRL 13137.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1509407 {ECO:0000313|EMBL:KNG85344.1, ECO:0000313|Proteomes:UP000037505};
RN [1] {ECO:0000313|EMBL:KNG85344.1, ECO:0000313|Proteomes:UP000037505}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 13137 {ECO:0000313|EMBL:KNG85344.1,
RC ECO:0000313|Proteomes:UP000037505};
RA Moore M.G., Shannon B.M., Brian M.M.;
RT "The Genome of the Aflatoxigenic Filamentous Fungus Aspergillus nomius.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNG85344.1}.
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DR EMBL; JNOM01000161; KNG85344.1; -; Genomic_DNA.
DR RefSeq; XP_015406267.1; XM_015551579.1.
DR AlphaFoldDB; A0A0L1J0Q4; -.
DR STRING; 1509407.A0A0L1J0Q4; -.
DR GeneID; 26808127; -.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000037505; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000037505}.
FT DOMAIN 246..365
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 82208 MW; FD4FA7268DDC6ADC CRC64;
MDPEMDVDAP EPRGTKRAAE EIEASKKPKR IRALDPDVVN KIAAGEIIVA PMHALKELIE
NAVDAGSTSL EILVKDGGLK LLQITDNGHG IDRDDLPILC ERFTTSKLKQ FEDLTSIGTY
GFRGEALASI SHIAHLTVTT KTAGSSCAWR AHYSDGKLVP PKPGQPATPK ATAGRGGTQI
TVEDLFYNVP TRRRAFRSAS EEYAKILDVV GRYAVHCSGV AFSCRKHGDS GVSISTPVAA
NTIDRIRQIH GSAVANELVE FKAEDQKLGF RSSGYVTNAN YHVKRTVILL FINHRSVEST
AVKRAIEQTY SSFLPKGGHP FAYIDLEIEP HRVDVNVHPT KREVNFLNED EIIDFICQEI
KSKLTQVDSS RTFLTQTLLP GVRTMEPAPH DPESTDAEDR TPKTPATTKK PYEHNLVRTD
SKVRKITSML PPAVLNTTET EPTSSVLDQG LQYETTDREP LRIALTSVKN LRASVRNAMH
NTLTETIASH TYVGIVDERR RITAIQSGVK LYLVDYGMFC NEFFYQIGLT DFGNFGVIRL
DPAPKLTDLL QIAAEAEREA SSSRKANSSE ENEENNIFDN APDLVARSLI DRREMLNEYF
SLEISAAGEL LSLPLLLKGY LPCLGKLPRF LLRLGPYVDW TSEEDCFRTF LRELAAFYTP
EQLPPPPSPA ENDENKESPD VDTEDELIRN RRLQIARMLE YVVFPALRSR LVATNRLLRG
VVEVADLKGL YRVFERC
//
