ID   A0A0L1KKR5_9EUGL        Unreviewed;       825 AA.
AC   A0A0L1KKR5;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   22-FEB-2023, entry version 16.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=XU18_4156 {ECO:0000313|EMBL:KNH04668.1};
OS   Perkinsela sp. CCAP 1560/4.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Prokinetoplastina;
OC   Ichthyobodonidae; Perkinsela.
OX   NCBI_TaxID=1314962 {ECO:0000313|EMBL:KNH04668.1, ECO:0000313|Proteomes:UP000036983};
RN   [1] {ECO:0000313|EMBL:KNH04668.1, ECO:0000313|Proteomes:UP000036983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCAP 1560/4 {ECO:0000313|EMBL:KNH04668.1};
RA   Tanifuji G., David V., Flegontov P., Gerasimov E., Hashimi H.,
RA   Logacheva M., Maruyama S., Onodera N., Gray M., Archibald J., Curtis B.,
RA   Cenci U., Lukes J.;
RT   "Draft genomes of Paramoeba pemaquidensis and its kinetoplastid
RT   endosymbiont Perkinsela sp. CCAP 1560/4.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KNH04668.1}.
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DR   EMBL; LFNC01000332; KNH04668.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L1KKR5; -.
DR   EnsemblProtists; KNH04668; KNH04668; XU18_4156.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000036983; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000036983};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        421..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        452..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        539..560
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        572..596
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        638..660
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        768..788
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          96..123
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   825 AA;  93249 MW;  E7E78FCE69969EDD CRC64;
     MSKPNNLWRS EPMYRMKLQM QREDAHDTII LLGHTGVVQF NDVNPTGSPL HRAYTPHLRR
     CDDIERRLQY FREQIAEMPV PREHSPVDES VSIKSYQLKK GMLEILEVQL ERIEQELREI
     TSRYGVMLGE MNKQREMREV FSQEDSFYWG ESCSMNDRSN ENRPETTLFL IVGVIPSSSV
     YMLEKLTYRI TRGNSYIRTA AIAEPFIDQT SSAEVNKSVF AIFFAASLFY PKIMKVCESL
     DGHVYPYADL DPSKVLPEVI TQCETMTQAI QKTQLARNEL LQSISPHIST WARLVRAEKS
     VFEVLNRIDF NGMIAIADVW IPQCEIERIE AALHEADLLT NAQVSSILTL VENDRESHCH
     SKSDALKTPP TYFRTNKYTV VFQDIIESYG IARYREINPA VLSATTFPYL FGIMYGDLGH
     GLIMTFAAMG LIAFEARLAG SQNEIFNTVF QGRYLIFLMG AYSCYTGLLY NDTFGISTDI
     FSSGYIWGSI SSTSGKIMTP VEPSGLGVGL NTAPGRVAAF GIDAAWAETE NKLEFYNSIK
     MKCAIVIGVI QMIAGLVLSL MNHIHFGDWR RVFFQFIPEI VFLLCTFGYM AILIVLKWCT
     PFASTNDAPS LLETMTNFFL APGSVTQQLY RGQAGVQMIL LFIALLMIPT LLIPIPYLAW
     RDKRRKTLNA RANPKIDSFL DNSNCGSHGN VYENSDQGTD SAGADEVDLS EIIIHQVIHT
     IEFVLGSVSN TASYLRLWAL SLAHAELSDV FWNFTLLKAI SAESGHGIVV FIGIAVWLIV
     SIFVLLLMES LSAFLHTLRL HWVEFQNKFY YGDGTKFLPF DLNSI
//