ID   A0A0L1KZ55_9EUGL        Unreviewed;       588 AA.
AC   A0A0L1KZ55;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
DE            EC=5.3.1.9 {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
GN   ORFNames=XU18_0045 {ECO:0000313|EMBL:KNH09360.1};
OS   Perkinsela sp. CCAP 1560/4.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Prokinetoplastina;
OC   Ichthyobodonidae; Perkinsela.
OX   NCBI_TaxID=1314962 {ECO:0000313|EMBL:KNH09360.1, ECO:0000313|Proteomes:UP000036983};
RN   [1] {ECO:0000313|EMBL:KNH09360.1, ECO:0000313|Proteomes:UP000036983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCAP 1560/4 {ECO:0000313|EMBL:KNH09360.1};
RA   Tanifuji G., David V., Flegontov P., Gerasimov E., Hashimi H.,
RA   Logacheva M., Maruyama S., Onodera N., Gray M., Archibald J., Curtis B.,
RA   Cenci U., Lukes J.;
RT   "Draft genomes of Paramoeba pemaquidensis and its kinetoplastid
RT   endosymbiont Perkinsela sp. CCAP 1560/4.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC         Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC         EC=5.3.1.9; Evidence={ECO:0000256|ARBA:ARBA00029321,
CC         ECO:0000256|RuleBase:RU000612};
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 2/4.
CC       {ECO:0000256|ARBA:ARBA00004926, ECO:0000256|RuleBase:RU000612}.
CC   -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|ARBA:ARBA00006604,
CC       ECO:0000256|RuleBase:RU000612}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KNH09360.1}.
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DR   EMBL; LFNC01000001; KNH09360.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L1KZ55; -.
DR   EnsemblProtists; KNH09360; KNH09360; XU18_0045.
DR   OrthoDB; 1657888at2759; -.
DR   UniPathway; UPA00109; UER00181.
DR   Proteomes; UP000036983; Unassembled WGS sequence.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05015; SIS_PGI_1; 1.
DR   CDD; cd05016; SIS_PGI_2; 1.
DR   Gene3D; 1.10.1390.10; -; 1.
DR   HAMAP; MF_00473; G6P_isomerase; 1.
DR   InterPro; IPR001672; G6P_Isomerase.
DR   InterPro; IPR023096; G6P_Isomerase_C.
DR   InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   InterPro; IPR035476; SIS_PGI_1.
DR   InterPro; IPR035482; SIS_PGI_2.
DR   PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR   PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR   Pfam; PF00342; PGI; 1.
DR   PRINTS; PR00662; G6PISOMERASE.
DR   SUPFAM; SSF53697; SIS domain; 1.
DR   PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR   PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR   PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE   3: Inferred from homology;
KW   Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW   ECO:0000256|RuleBase:RU000612};
KW   Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000612};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000612};
KW   Reference proteome {ECO:0000313|Proteomes:UP000036983}.
SQ   SEQUENCE   588 AA;  64864 MW;  AE074817E7F0B6BE CRC64;
     MHSKTHSSAP SKLSQEWLAL VDYHKGLRKC QLSSFLTGEQ PDVSERVKQL TIRVDLGEEN
     FLHADFSKNY LTQESIGLYT RFAEEKKLGD KIHELMNGGV LNHSEGRNVS HVVLRSHKVL
     TQLKKTEQPA ELSAEELVVF STLKKIERIC DAVVNGKLQS AKNVPFRHVV NIGIGGSDLG
     PCMACESLEE FSTQPKSDLS FHFISNIDGN ALHDTLKEIS VSDSLFIIAS KSFTTGETMA
     NMNSILGVLH DELMEKGVLP RGGSATLANS PMLRRHFIAV SCRGDNVKKS GFDTESDAYL
     NFNEGVGGRY SLWGPVGLSI ALKCGFSSFV QLLEGAQLVD AHTSNTSLDN CAPFLMACAE
     ITYNNFFGWR NRAVVPYNQR LSSLVAYLQQ LEMESNGKRV TASGDRAVDV DTCPVVFGGS
     GTNSQHAFFQ LLHQGTDTVP VDFIIALQKG NDMSDLHQDW LVANCFAQSQ ALLMGDRRLV
     VDGNRISADR STASADLCRQ FTGDRPSTTL ITQRLTPLSL GALLALYEHK VFIESILWEV
     NAFDQWGVEL GKQIAHSIYR EISDSDSPQS PHDASTAEML NLYKQVKH
//