ID A0A0L7M2M9_PLAF4 Unreviewed; 813 AA.
AC A0A0L7M2M9;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Nucleotidyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFDG_02751 {ECO:0000313|EMBL:KOB87068.1};
OS Plasmodium falciparum (isolate Dd2).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57267 {ECO:0000313|EMBL:KOB87068.1, ECO:0000313|Proteomes:UP000054282};
RN [1] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Kodira C., Zeng Q., O'Leary S., Yandava C., Alvarado L., Wirth D.,
RA Volkman S., Hartl D.;
RT "The genome sequence of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS016440; KOB87068.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L7M2M9; -.
DR EnsemblProtists; KOB87068; KOB87068; PFDG_02751.
DR OMA; DICFDTP; -.
DR Proteomes; UP000054282; Unassembled WGS sequence.
DR GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:InterPro.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProt.
DR CDD; cd05402; NT_PAP_TUTase; 1.
DR Gene3D; 1.10.1410.10; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002058; PAP_assoc.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR InterPro; IPR045862; Trf4-like.
DR PANTHER; PTHR23092:SF15; INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED; 1.
DR PANTHER; PTHR23092; POLY(A) RNA POLYMERASE; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR Pfam; PF03828; PAP_assoc; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054282}.
FT DOMAIN 409..515
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 575..628
FT /note="PAP-associated"
FT /evidence="ECO:0000259|Pfam:PF03828"
FT REGION 14..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 813 AA; 96558 MW; B40509A23C119C65 CRC64;
MEKASNIIWL GQDDDNLKNE YKKHNEGKHN RDRKKSAEDI NILSSDKRNI INRRNDEFTK
KYEQDKYHSY DGRHDNDDDV DSFPFNDIQN KKRKKETSYS KNEMEYGYCE HKDSFDKYNN
KKKIRKNDDM YHEPNNNNNN NNKYNYYGSN NNNHDNVEHK KLNNKEENIT DPNVKYLSNL
NNQNNLDDKE KKNKLLDSKG RSNNSHIITV SSNSSLSSDD STSTNYLPSS KKRKNINETC
YSNKYSKDSN NIIIEGSGYN MKKKSLSRNK SYKEEKRKNS SFLLNDANVE HGIHNKEYEA
RDRNTTNNVL KSNIHKNILK KFKINYKNLS SMEKEYYNYM IKKLDINYDD EKKVLYTDSL
FNEKFSYMVS KENKNFNFLG YLEYSCFYIL EWLTPSKEEK LLKLKSLIKL ELLVKSLFPK
SKIEVFGSYT SGLSLPSSDI DVCIMNIKEN ELDCLYILAY ALIKLNIACD IRIIKDARVK
ILKYIDKELG VQIDICINQK SSKETTDFII TQMKKYIYLR PLVLLLKFFL HSRNLNETYI
GGIGSFLLSC MVLHFLQMHT STFDNNHFNN TYLIKLLIEF FYFYSIDFKL HDACIVVRGL
GHVLPRRLRK EYEYNDQRLC FENPIDTSID IGRNTYRIKY ILYLFSYTYC NFISLISKLR
KHSNNFHFPY IPNVDEQSHT KNKKNGKPLE NKNCKINNNT KKNYIYGSKI KSNCIYPLFY
GNIFNPDNII FTKRYKKNFP SNDWDIRHFD FIFTKQEINN MFNMSCEDLN SYVNMDYMIM
NTSSMLYANI DKIFSHSFDV YNNIFKYSTS HDI
//
