ID A0A0L7R6Q7_9HYME Unreviewed; 530 AA.
AC A0A0L7R6Q7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase {ECO:0000313|EMBL:KOC66560.1};
GN ORFNames=WH47_08953 {ECO:0000313|EMBL:KOC66560.1};
OS Habropoda laboriosa.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Habropoda.
OX NCBI_TaxID=597456 {ECO:0000313|EMBL:KOC66560.1, ECO:0000313|Proteomes:UP000053825};
RN [1] {ECO:0000313|EMBL:KOC66560.1, ECO:0000313|Proteomes:UP000053825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0110345459 {ECO:0000313|EMBL:KOC66560.1};
RA Pan H., Kapheim K.;
RT "The genome of Habropoda laboriosa.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the phosphoglycerate
CC mutase family. {ECO:0000256|ARBA:ARBA00008408}.
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DR EMBL; KQ414646; KOC66560.1; -; Genomic_DNA.
DR RefSeq; XP_017788994.1; XM_017933505.1.
DR AlphaFoldDB; A0A0L7R6Q7; -.
DR STRING; 597456.A0A0L7R6Q7; -.
DR EnsemblMetazoa; XM_017933505.1; XP_017788994.1; LOC108571449.
DR GeneID; 108571449; -.
DR OrthoDB; 2013830at2759; -.
DR Proteomes; UP000053825; Unassembled WGS sequence.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR PANTHER; PTHR10606:SF65; 6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2, 6-BISPHOSPHATASE-LIKE PROTEIN; 1.
DR Pfam; PF01591; 6PF2K; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR PRINTS; PR00991; 6PFRUCTKNASE.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:KOC66560.1};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053825};
KW Transferase {ECO:0000313|EMBL:KOC66560.1}.
FT DOMAIN 97..305
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT REGION 511..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 315
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 384
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 314..321
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT BINDING 364
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 530 AA; 59800 MW; 95B5A53F6742ADA7 CRC64;
MPWVAACFDL LAAPILGYCL AVRKLGLQAG ILQQGGDKSV KTLADNTSDT SSLRKDKLLS
ADTMAPSVEE QRQEHSKDKI AVRPPTIITK SPRKFAGVVI AMCGLPGRGK SQVAVCLSRR
LNWNGDSTKV MRVSDYRRKR LEPYGEAVSH ELFRPDHTAN AALRALAQRD AMHDCAAWLA
AGNSVAILDA TLVTRMQRAE VYDYFSGQLG YHVLFVECAC DDPLVLERNY KEILRYSADY
IGMDPVRAEE DLRLKVAHYV RCYEPMDENT YPRIRINIAT MDIETCKVSG HVETSVLGYL
GSVSVKPHTL YFSRHGESEF NVLGKVGGDA VLSTRGERYA QALATKFNAM RIPDLRVLTS
RLRRTIATAR GVEAPQEHVA ALNELHAGVC EGLSYEEMQE HYPQEFAWRD QDKLRYRYPW
GESYIDAMQR VDPVIAELQR SDNILVVSHQ AVLRCMIGFF LDKKPEELPY MEVPLHTIIR
VTSHGYNYKL EFFKLPIECV NTTRVTVPPH FDMPDPWRNP GNGPTLVQQH
//
