ID A0A0L7RFM3_9HYME Unreviewed; 713 AA.
AC A0A0L7RFM3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 08-NOV-2023, entry version 30.
DE SubName: Full=Hemocyte protein-glutamine gamma-glutamyltransferase {ECO:0000313|EMBL:KOC69777.1};
GN ORFNames=WH47_07517 {ECO:0000313|EMBL:KOC69777.1};
OS Habropoda laboriosa.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Habropoda.
OX NCBI_TaxID=597456 {ECO:0000313|EMBL:KOC69777.1, ECO:0000313|Proteomes:UP000053825};
RN [1] {ECO:0000313|EMBL:KOC69777.1, ECO:0000313|Proteomes:UP000053825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0110345459 {ECO:0000313|EMBL:KOC69777.1};
RA Pan H., Kapheim K.;
RT "The genome of Habropoda laboriosa.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; KQ414599; KOC69777.1; -; Genomic_DNA.
DR RefSeq; XP_017797412.1; XM_017941923.1.
DR AlphaFoldDB; A0A0L7RFM3; -.
DR STRING; 597456.A0A0L7RFM3; -.
DR EnsemblMetazoa; XM_017941923.1; XP_017797412.1; LOC108578560.
DR GeneID; 108578560; -.
DR OrthoDB; 5344745at2759; -.
DR Proteomes; UP000053825; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590:SF40; HEMOCYTE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE-LIKE PROTEIN; 1.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR Pfam; PF00927; Transglut_C; 2.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000053825};
KW Transferase {ECO:0000313|EMBL:KOC69777.1}.
FT DOMAIN 275..373
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT ACT_SITE 283
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 347
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 370
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 410
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 412
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 467
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 472
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ SEQUENCE 713 AA; 80574 MW; 8BDC4FCC94B1EB81 CRC64;
MFEEPLVVEN VHMYEKENAK VHHTINYELV HLDPPAAVLR RGQTFNVALR FNREYVDDTD
IVRLLFSFGP NPNVLKGTRG VNTVTNRDSY LTDLEAWGVR MVGLSGMDLS VEVRSPVDSP
VGLWQLNVET TTVARKKQAP RTYNYDKDIY LLFNPWLKED LVYMEDEQLL DEYVLNDVGK
IWVGPWGSSR GREWVFGQFD AVVLPAIQLM LERSGIKAIS RGDPVKMCRA ISRIINSNDD
RGVITGRWDG DYADGTAPAT WTGSVPILEE FLETGESVKY GQCWVFAGAV TTVCRALGIP
SRVVSNLVSA HDANASLSVD RYYNTENEEL EYDPNNLNGE DSIWNYHVWN DVWMARPDLP
KGYGGWQAID ATPQETSDGV YQCGPSSVEA IRQGAVGYNY DVTFMIASVN ADLMRWKEDP
ETELGYSKID CNKYHIGRMI LTKAPWIFDP NGDRDREDIT LLYKAKEGTE AERLTLYRAV
RNTEVAKRFY SMPSGAKEDV EFDLVDLDRV NIGQPFAVTV HMKNKSNQLR TIQAILSAGS
VYYTGVKANL IKRASGDFVL QPNASEQLRL TVTVDDYLDK LVEYCIMKLY CIATVKETRQ
TWADEDDFQV LKPNIEVKID GDPTVGRPST ITLRFKNPLR RPLTECKFNY AGPGLSKNKT
LMFRDVEPEE DVYVEHQLIP QKGGAQKIIA TFTSKQLLDI TGSAAIDVLD EDE
//
