ID A0A0L8FYR3_OCTBM Unreviewed; 349 AA.
AC A0A0L8FYR3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819};
GN ORFNames=OCBIM_22004156mg {ECO:0000313|EMBL:KOF69714.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF69714.1};
RN [1] {ECO:0000313|EMBL:KOF69714.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF69714.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF69714.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|ARBA:ARBA00003993}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573}.
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DR EMBL; KQ425220; KOF69714.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8FYR3; -.
DR STRING; 37653.A0A0L8FYR3; -.
DR EnsemblMetazoa; Ocbimv22004156m; Ocbimv22004156m.p; Ocbimv22004156m.g.
DR OMA; CENGARI; -.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 222..334
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
SQ SEQUENCE 349 AA; 39476 MW; BC0B53CFC18C959F CRC64;
MERRLAKGDN LLTGKPSCQP FKVKLVRGSD GVWVLQGSPN KTKEVFRGDC KTECRAMAFS
MNGQYFAWSD EDGIKVMKTS NYEKVMAIEK SRISGLAFSP LGTYLISADI SSQKKDVPNL
CIWETATGKL LKGFFHKRMS DWKPSWTPDD KLMVRLHNND VEFYENGDFD NPKTRLHAAK
ISEYAFSKSD HVAIYIPGSK GQPSNIRIFK HPNFNGCPLA NKSFFKADKI TMYWNKAGTG
LLVITSTETS DKSYYGETGL HYLSIKGEGC LVPRAKDGPV YCVEWHPNST QFCVVYVMPA
KATLYNLKCD PVFDYGTAPR NSAFYNPQGN NILLRYTSPL WKMSFLRDM
//
