ID A0A0L8GF81_OCTBM Unreviewed; 490 AA.
AC A0A0L8GF81;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Purple acid phosphatase {ECO:0000256|RuleBase:RU361203};
DE EC=3.1.3.2 {ECO:0000256|RuleBase:RU361203};
GN ORFNames=OCBIM_22034381mg {ECO:0000313|EMBL:KOF75667.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF75667.1};
RN [1] {ECO:0000313|EMBL:KOF75667.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF75667.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF75667.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC Evidence={ECO:0000256|RuleBase:RU361203};
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. Purple
CC acid phosphatase family. {ECO:0000256|RuleBase:RU361203}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ422024; KOF75667.1; -; Genomic_DNA.
DR RefSeq; XP_014781554.1; XM_014926068.1.
DR AlphaFoldDB; A0A0L8GF81; -.
DR STRING; 37653.A0A0L8GF81; -.
DR EnsemblMetazoa; Ocbimv22034381m; Ocbimv22034381m.p; Ocbimv22034381m.g.
DR EnsemblMetazoa; XM_014926068.1; XP_014781554.1; LOC106877215.
DR GeneID; 106877215; -.
DR KEGG; obi:106877215; -.
DR OMA; CKDVFEP; -.
DR OrthoDB; 203742at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd00839; MPP_PAPs; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041792; MPP_PAP.
DR InterPro; IPR008963; Purple_acid_Pase-like_N.
DR InterPro; IPR015914; Purple_acid_Pase_N.
DR InterPro; IPR025733; Purple_acid_PPase_C_dom.
DR PANTHER; PTHR45867:SF3; ACID PHOSPHATASE TYPE 7; 1.
DR PANTHER; PTHR45867; PURPLE ACID PHOSPHATASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF14008; Metallophos_C; 1.
DR Pfam; PF16656; Pur_ac_phosph_N; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|RuleBase:RU361203};
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..134
FT /note="Purple acid phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16656"
FT DOMAIN 146..352
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 377..439
FT /note="Iron/zinc purple acid phosphatase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14008"
SQ SEQUENCE 490 AA; 56812 MW; 7B30F67384112EA4 CRC64;
MEISGLNECR RFAILLLTFY NVLLLCSTTP IYNGYPTTKF NPYLPEQIHI AYGEDYSMII
TWSTFKSGLN TIVKYGTDSL SHVAYGKAQR FINPDLYFHT QYIHVVTVPN LQPGVKYIYR
CGSPQGWSEQ FSFTAKRNDS SWAPMIALFG DMGSVNAQSL PRLLKEVKQN LYDSIFHVGD
FAYDMHKGHG EVGDKFMQLI QPMAANVPYM TCPGNHEAYA NFSNYKNRFH MPGDIDSDNM
FFSFDIGPAH VISFSTEYYF FIEYGLYQIE HQYHWLEADL KKANEPANRA KRPWIITMAH
RPMYCSNNDK DDCTKSESLV RKGVPIIHAY GLEDLFYKYG VDLEIWAHEH SYERLLPIYD
RHIYNTSSIN PYDNPEAPVH ITTGSAGCSE KHDPFANKTA PWSVFRSLDY GYTRMKIYNS
SHLYTEQVSD DKDGEVIDKM WLIKDTHGPY KDKTLRYNAK NEEALKRMES VNRKSIFANQ
KKMSFRTIER
//
