ID   A0A0L8GKU2_OCTBM        Unreviewed;       754 AA.
AC   A0A0L8GKU2;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Glutamate receptor {ECO:0008006|Google:ProtNLM};
GN   ORFNames=OCBIM_22031885mg {ECO:0000313|EMBL:KOF77616.1};
OS   Octopus bimaculoides (California two-spotted octopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX   NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF77616.1};
RN   [1] {ECO:0000313|EMBL:KOF77616.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF77616.1};
RC   TISSUE=Gonad {ECO:0000313|EMBL:KOF77616.1};
RA   Tran T., Druce J.;
RT   "MeaNS - Measles Nucleotide Surveillance Program.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KQ421372; KOF77616.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L8GKU2; -.
DR   EnsemblMetazoa; Ocbimv22031885m; Ocbimv22031885m.p; Ocbimv22031885m.g.
DR   EnsemblMetazoa; XM_014924587.1; XP_014780073.1; LOC106876162.
DR   OMA; TMDMELF; -.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR001508; Iono_Glu_rcpt_met.
DR   InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR   InterPro; IPR001320; Iontro_rcpt_C.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR   PANTHER; PTHR18966:SF422; KAINATE-TYPE IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT 1D; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00060; Lig_chan; 1.
DR   Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR   PRINTS; PR00177; NMDARECEPTOR.
DR   SMART; SM00918; Lig_chan-Glu_bd; 1.
DR   SMART; SM00079; PBPe; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        407..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        478..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        664..688
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          279..640
FT                   /note="Ionotropic glutamate receptor C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00079"
FT   DOMAIN          289..351
FT                   /note="Ionotropic glutamate receptor L-glutamate and
FT                   glycine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00918"
SQ   SEQUENCE   754 AA;  85246 MW;  58E49C00E951A7F3 CRC64;
     MFFYGGGQSI RSTPVRNWYL IYRPRKDEGQ SRLRWNLKPE RKVRRNTVKH LTRRANVSYF
     FIAHKGLNIE GDRQGRTKGL SRLHRPQCEK QQQLVLVLVV AVLVVDLTLI DLEEFKYGGA
     NITAVRMIDS LRPFVSEVTQ DWVMEEKRTG NSPIKGLKTE IPTETALMYD AVYLFAKALH
     QVAAARDINT MALSCTKQNT WNHGNSVLNY MKTVVFDGLS GRVMFDHKGE RSDFSLNVLK
     LKEQGLSKIG TWDSTNGVNI TESKTETKHE LQKKLANSTL RVVTKLELPY VGNKTAPDGT
     VEYEGFAIDL LNAIAEELHF NYTISIVKDG QYGGEDPLTG KWNGMVGELI ERKADLAVAG
     MSITYKREKV IDFTKPFLNL GITILYKKPM KKPPKLFSFL SPLTSEVWVY IIAAYLVVSF
     MLYIIARLSP YEWYESGSDE LDNQFTVLNS LWFTIGCLMQ QGSEVAPRAV STRIVSGIWW
     FFTLIMISSY TANLAAFLTI DRLDTTIESV EDLAKQTDVH YGTLKGGSSK AFFEDSDVPT
     YKKMANFMQS TTPSVYVSSS REAVQRVLKE NYAYLGESTS IDYQVQRNCQ LMQVGGLLDS
     KGYGIATPRG SPYRDMISEQ ILLLQERQEI SKLYTKWWKE KAANKCDNES KGKQNANELG
     LQNVGGVFVV LMAGVVAGTI MAIFEFLWKS WRNSRIDKQP FCTEVSQELR VAITCLGSSR
     KNGKTKSDDA RLDNHQLVPL TSGQNSFLTK DMNT
//