ID A0A0L8GVK0_OCTBM Unreviewed; 493 AA.
AC A0A0L8GVK0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Beta-glucuronidase {ECO:0000256|ARBA:ARBA00016205};
DE EC=3.2.1.31 {ECO:0000256|ARBA:ARBA00012761};
DE Flags: Fragment;
GN ORFNames=OCBIM_22027010mg {ECO:0000313|EMBL:KOF81086.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF81086.1};
RN [1] {ECO:0000313|EMBL:KOF81086.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF81086.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF81086.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the degradation of dermatan and
CC keratan sulfates. {ECO:0000256|ARBA:ARBA00003025}.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
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DR EMBL; KQ420162; KOF81086.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8GVK0; -.
DR STRING; 37653.A0A0L8GVK0; -.
DR EnsemblMetazoa; Ocbimv22027010m; Ocbimv22027010m.p; Ocbimv22027010m.g.
DR EnsemblMetazoa; XM_014922142.1; XP_014777628.1; LOC106874416.
DR OMA; HRTEGDR; -.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0004566; F:beta-glucuronidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR10066; BETA-GLUCURONIDASE; 1.
DR PANTHER; PTHR10066:SF67; BETA-GLUCURONIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 1..89
FT /note="Glycosyl hydrolases family 2 sugar binding"
FT /evidence="ECO:0000259|Pfam:PF02837"
FT DOMAIN 91..189
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 191..462
FT /note="Glycoside hydrolase family 2 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02836"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KOF81086.1"
SQ SEQUENCE 493 AA; 56635 MW; A36AC88F81747A2C CRC64;
WVNSEFAFNH SGGHLPFEGD VTHLLKYDRA ERVTVAVNNT LSPTTLPPGT ITYKTDSKRY
PKGYFVQNLQ MDFFNYAGIH RNVWLYATPQ TYIMNIYIDT SIQKSSGIVT YEVIPNHYTK
GQRYKVKVIN EYGNLVASSN QSTDVLKISN ANFWWPYTMN TSSPAYLYTM EVTLISDTVD
IYRHPFGIRT VKVNSRQLLI NDQPFYCLGV GRHEDADVRG KGVDLPFIAK DFNLMKWLGV
NCFRTSHYPY SEELMDEADR QGFAVIDESP GVGIEKNNME EANLIHHKNV MLELVDRDKN
RPSVIIWSVA NEPSSYLPKA EGYFKSIIRF TQMLDKSRPV TFVMNANVFT DKAAQFADIL
CINRYFGWYS DMGHPEVVPL QLPYELDNFH ALHRRPVILT EYGADTVNGL HRSPSIAFTE
EYQVNLLTAT HEALDKRIGT YMAGEMVWNF ADFQTDQVHS DFQKARMDKA GQEGVTEEVT
GRVMKDFRQR TLK
//
