ID A0A0L8H0X2_OCTBM Unreviewed; 1254 AA.
AC A0A0L8H0X2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Nephrin {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22025285mg {ECO:0000313|EMBL:KOF82450.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF82450.1};
RN [1] {ECO:0000313|EMBL:KOF82450.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF82450.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF82450.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KQ419759; KOF82450.1; -; Genomic_DNA.
DR RefSeq; XP_014776690.1; XM_014921204.1.
DR AlphaFoldDB; A0A0L8H0X2; -.
DR STRING; 37653.A0A0L8H0X2; -.
DR EnsemblMetazoa; Ocbimv22025285m; Ocbimv22025285m.p; Ocbimv22025285m.g.
DR EnsemblMetazoa; XM_014921204.1; XP_014776690.1; LOC106873723.
DR GeneID; 106873723; -.
DR OMA; CEVSNIM; -.
DR OrthoDB; 2875972at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR PANTHER; PTHR11640:SF136; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 2.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 8.
DR SMART; SM00408; IGc2; 7.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 8.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1004..1029
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..97
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 105..204
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 214..303
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 308..403
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 411..498
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 504..595
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 698..780
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 791..886
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 893..985
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1050..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1254 AA; 139845 MW; 1B2CE40648896474 CRC64;
MFRTKPQNVS AIKDQTVILK CEVMNQSGLM QWSKNGFALG YDKSIPGFSR YEVVGNLNLG
EYNLMITNVE LRDDTEYQCQ VLPTPGNPAL MASAYLTVHI PPDVPKIVGH KNASTIDIPY
TQDEIKLECV AHNGRPAARL EWFKDGEKIT TGISYRTETK PGEKLSTAIS VLTYRPKFNY
NDALLSCQAS NDAVQGPPLE TFVQLSISFP PGEPHISGYH EGQVVRINDT LHLKCVSEGG
NPPALVIWYK NNKEIDRSYF TEQNKAENDL TLTVESSDND AIFKCEASNT ATVNPLVASF
KLTVHFPPKK VKISGHRLAK AGQTVTLKCV STNSNPAATI TWFARGRQLP DENTQVKSSP
KGGFISTSIT KVNLTGNDNN VMYTCVAKNE YIVGGTSDSV TLSVLYPPAS PTISGYSPGS
AVHSGETAKL TCTAIGGNPL ASLKWYTRGR RLDSDYKIIG NIASADLNII IKPEDNGAIY
VCKATNNATV RPLQTQIRLK VFFPPVSVNI TTKPDQARAG QKYTLTCECS SSNPEAEIIW
LHNSQRLQGN NLALMNGSNG GKITINILEI IPTPDDHMAV YGCRAINHAV DKAVNDGITL
DILFKPVFNT LIPHKISILE DEWKSVNFSV RANPEKVRYS LWRDGRVLKL PRNFLLDDDG
LLNLTKVKQK DSGDYQIKAV NKEGATFLNF TVDILYAANI THISTPVIED EGGIAYLECI
AEANPMSDNM VGWTRDSYDM SRTRQTYDKG SSSLTVYELS RTDAGTFTCS AYNGYGKVVT
RVAQLIVKYP PQIDQSRQYA KAASEKGGTA TLICKADGAP LITFSWSKGS AELKNSDKYN
IKGTKDGDVY YTSLLEISNV TKEDYGKYLC KAKNVEGSAE SEILLDGTSK PDPPYNIKFV
NATHNSLTLT WQPGFNGGMT QSFRVRYRPK GTTNYKYVDV GPGSNVYLLT GLQKGKEYEI
TMLAFNKLGE SKYQRKEFIA KTSNLNPPEE HDAAPPQDSD DMPLIIILVV CIVGIFLLAL
NIGLIMFFIR RKRKRLERHL EWYALHSSNH SGTNETIPRQ RDGSDTTSHT NTFELFGSTK
ESHLYPMSPS EDARSYDTYD KSLDEFSDEC SKNYEFLPFQ DEDMKRVFLP PHDYSDRPYT
PCKQDSPHVE PKRIYMDSPN RQIAYLDDSD TRLPNEDLYM TPKKKTETFE PNHYGVIRGK
TPPGNIYEDT NWSRQEQNSR MRNGMVGDYL ERAPSRPCSR AVTYQWNTQT QSSV
//
