ID A0A0L8HH70_OCTBM Unreviewed; 1498 AA.
AC A0A0L8HH70;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22014863mg {ECO:0000313|EMBL:KOF88469.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF88469.1};
RN [1] {ECO:0000313|EMBL:KOF88469.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF88469.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF88469.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ418184; KOF88469.1; -; Genomic_DNA.
DR EnsemblMetazoa; Ocbimv22014862m; Ocbimv22014862m.p; Ocbimv22014863m.g.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR PANTHER; PTHR45899:SF2; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 3..67
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 442..538
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 644..771
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 854..952
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1053..1255
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 215..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1498 AA; 171485 MW; 2B22E12F97802FC5 CRC64;
MDPNFDRLCH WLKQMELEQY APLFKKSGII NLDQCAHLNS EKLDKLGVNL SGHRKRILAN
LPNTNDYCLA ANLYPESPES VHPPLLPPKI KPVHRKDADA LFGVSTPTSN SDCSSLFEKP
VPRPRTTVKK TSEEEILRPI PKPRARTTTP VHELESKTIG AIPPSITTSI IPPVVSTTES
LNISMRDKAN GSQGSEHQAL RSRSTLLAFD PLFTGEINNN DSSDAKKPKN WTDTNKNPPV
SDSGSSARSK SEVYEDLWRL KSKTPVKSFQ SFQKNAISED ENNCDNHLSS DEDFDMKPPP
YPPPQLPLNQ APPIPPRINE KPKSIEDDDI IDAFPNNDPF VDFSSECDLF NKKPCLTISD
EFGPFGHFRD TFCPNTRPYL YPSLSGLGAM SQADSVLLDG TSDDDDSTSD EESSVNVSLT
TSTERIAPGG AKITSGVSSP RSSERSGYLY KQGGVQGNKG WRKRWVIFNG SDLRYYVNPK
TQISKRIIPV SCMQDVQQDI KETQYKFILK TKYRNFLFYA DTLDDNILWC STLIEAIHKY
RPPANGFAAG GSMSYPDKKG IIKFETERAK VFVALKGSIL CYYHNQRDYE IASPIHEIDM
KLAAVKELAR NKLQLCTHYC NINMVFDNPQ ETKEWKLVLT NAIDSALVDL QIARKIWENN
SNKHCADCGM EEPTWAAIDL GMVFCLKCSG IHRDFNIVKS MTLDVKVWTT SLIELLLRIG
NENANNFWEF NKNPDFVIDW DTNEAERKLF IENKYKNKAF VNYYHCYKNH EELNEALLKA
AQDDDILKTM RILYSGADIN YYSPNNPNMT AYQLAKSSGQ RLQIEFLLQN QCERKMSSQQ
ESGDELALSS KRNGVNYEGY LLKTGVNMKD FLRRWCLLEH GRLSYYADKK NTAARGSIEN
TQMLVIQATH TEKYKHSFEL STTQNNNRIY QFATDELEEQ TKWMQAIAKV FSPNEGFSKI
SESMFDLAGI FYIKWHGIEW TKSWIMVSGK DLTYLTNEKT WEHLDLRKTI KMTKINTPDE
RCIGAIQNNG HCFVAVFPKI ALYLQADLQH DTERLATLMQ KATVTCQRFF NDQQLTADDV
PVVVDKCIKF IMTNGLHESG IYRQSGVKSQ IAKLLEIFHT DAQKVQLVVD TYNLPTVTGV
LKRFFREMAD SLLTKTLYEK WIKTAETDDT QAKLNWYKYL IKELPLVNQN TLKKLVTHLW
SVAENEHSNK MGIDQLAIVF GPTLMSGGSS QNNYSNTNSE ITVIRELIKY HERLFELPVK
NKEIEKKIQE ACEKMENLKK VSVVSDSLLL HLYVGVYDSQ PIATTVSWTM NGGDILERVQ
PKICLKGVDW ILYETVCNGT LERPIHSTEN IEDVLSQYKF WDETDARETR LLVKQSHLCV
NFKEYFDPSK TLMAELEFCE KKVSRKYWFE FSQAKLSYYK DTKGSPIATW RIEDLNIYMG
IEQNRDPKLR PGFTFVVKNE KQKRSKDTPY FGKALYFPTV HDMYVWYAGM MFTKYPTV
//
