ID A0A0L8HT78_OCTBM Unreviewed; 2659 AA.
AC A0A0L8HT78;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=OCBIM_22007721mg {ECO:0000313|EMBL:KOF91950.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF91950.1};
RN [1] {ECO:0000313|EMBL:KOF91950.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF91950.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF91950.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR EMBL; KQ417446; KOF91950.1; -; Genomic_DNA.
DR RefSeq; XP_014769951.1; XM_014914465.1.
DR STRING; 37653.A0A0L8HT78; -.
DR EnsemblMetazoa; Ocbimv22007721m; Ocbimv22007721m.p; Ocbimv22007721m.g.
DR EnsemblMetazoa; XM_014914465.1; XP_014769951.1; LOC106868981.
DR GeneID; 106868981; -.
DR KEGG; obi:106868981; -.
DR OMA; GHQALIT; -.
DR OrthoDB; 8448at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1630..2205
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT REPEAT 1689..1722
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 2313..2622
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2627..2659
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2659 AA; 303675 MW; FEF888D4762FECD2 CRC64;
MASTMDFNLL LELLKKYKTT SDTSQLTHAM LHIGQSLYDL DSVAKKLAGP TASMCHFLLK
ITSDILDEFK FTKNQQPSQD SPDECEAFMY WFTSQLLSLF THPGCHQLHP KCVTLIVQFL
NSLKINEPYL YHKILEKLAC CLSELAVSES SGLESTDENK PIVLNLFNVD LRLISNFLPP
SEQNTEIRQA VIKLGCESCE ILQGNLTLVF SQQVRYLNGG WNTRLLSVLC PSLLAQIEYG
DVPLKAASLQ VIEQLLLLHG IPEFEQLEYL VAVLVAIPPM MYGDQAELTS KELSLMETAY
VKTLNALLKA DSSGIGNHLD IANLDLMLNK FIEFMSLCGW LQKLQQEPSA DMCSAVSSFL
NHILTKLKQI QNIFDSVYSP VINVLKEKLC HLLGRVYNKE FLVQNLCLLV SWEMESSCLN
ENDLSKETEE HQPKKAKLPY LPHLKSKTSN NSRKKITPED KSKLFMEIKR KLEMFKGKSH
NDSSGVLCML TGVQVIVEVS VLLFHSFKDN PLQKKTKDGQ PKVYSTDQKF TEWLSKEELT
EISYLWKNLF SLCTSLQNAD ESKVKELLNC SLQVIAKSVA ALLIVKDFSA AVPELVSEFV
VLLSLPWLAN NASWLDLHSA DLKPMLEISG RLSPLLDDLT CQICMEVLCW IPKYIAGQWR
CHIYKSVLAN NLSLPLILQG IRSSVVLLHT LGDNYAHLMT ELILPLFNMK NPTVDNSLAS
VFGELVCVLS GETEICQSNS FDSNGGEVNI FDLFKLKCKQ CDDAKTSHKM LVSQTKLPII
QEMFVCFSGY KDISDTAYRT ALAHSLLRVY NHVEIKLTEH WALNLLNYSL QLINDPDYDI
CILFSNCCWH LIKVSGLDVA NIVFEKLKNS LADLKDTKSV KLQKSILMTV GLLGKYSSGP
LLLDVTLFLL ENIVSDVPVS SAVAYMQLQG ISRAKKAGEK PFNIFMNYQQ PICMFLVKTM
DESCKLNIGK TAEQKLKEVS NVFDYVDIRA FIHSTERFLL PQLVAMASPT ASSLIKLLAT
LLQVPSRKKL LISSTKYIFS YLIRHHNEQE IAKALQFHFA ETEIELTYLL RIDFQRVHNE
LLLYLSTNYA EVFKGLQRLC SYDDFYRGQI ATTEDMANYL QPRLLGILAF FDSQLLISSI
PIEEKRLTLD SLNSIIQLMG AKHITFVRYK IMNTLRISLR FDEKDFLAIA CQAWNSFIRS
VELPALGDML SPISATLLPL IQQLPAQSAE IFNYLIIENK DALCSHFQEI YFLPDIPELS
NVNYVLKQYS SSLSSQSDLR TKITHTLRGV THESLDVQIH ALSNLRNLLH SSQRQLHQYM
LDNETADPIV SQLISVLLSV CKVPDHRVRC LIGDCLGEIG AIDPGRLELT SNNPKEEMAK
FQASTEDDNF AIGIINEIIR AFLAATETRV QDCASLALQD LLQIYKISDK PEENNEHGSE
RRLWNRFPEH VQEILQPLLN SKYISSSSFS WDNLQKPIYG SMKGSKYKEW ICIWTTYLSS
RVQQNHPLRV FQVCSPITRY DPSIALYILP HVVTQVLLDG TEGDIQDIYN EIMEVLHQIR
KSDTRQGSVT DMRHMCAQTI FSVLDYLSKW RTNRAQLKVA EMPISKEPVY LKDSSYRTVN
AFLNHIPQDV LAEACFNCNA FTRALMHFEH FIRNNDCNIQ QHLDLLQRIY VALDEHDGVA
GVAAIRQAQP TLVQQILAHQ SIGQYQDAEA CYERAVQLEP EEISHHHGWL RSLMELGQLN
KALLHADGII ANHPSWSTQL NTYRVEATSK LGDWSKLESY VKLEKESNDW VVSLGKILLA
IKDRHEESYQ KHMNSACIEI MGPLSAASME SFSYLRGYEY IVRLHMLNEI EQAKKIIFDS
KTLLKRSKSK QQSSSDSVSL DELLLQWDAR SKLMQSPFRI QEPVLTLRRT LITLESCSNC
SPQIGKWLLD TATAAREAGY LQTAYGSLIQ AASSNLPEYC LEKAKWFWEK GQNDQALSCL
EKGMAEHFPD LNQLKRDMSR SSKKKLFTYA QAQLLYTHYC DETSNTDSNT VLKQYRDVTD
SCSEWEDGYF FLAKYYDKMK NNLIDDNENS VKQGEFNIFV VKNYGTSLQY GNQYIYQSLP
RLLSLWLDYG STVVQSELRD QTSNQTSHIQ KLQSQKTILQ NLNKVIEQIS RKLAPYQLFT
AFSQLISRIC HANSDVFRHL VKIIAKLLYT FPAQAVWMLM AVSKSSYPKR VKRCQEIFNQ
AKLMKEELGK FLLDANKLTE RLLELSERHC PDTQPLSLSL HFKSLKRLLD DPNFSNIIVP
LQSSMTVTLP MTKTDNKVDH DPFPGDTVYI SSFEDTIEIL PSLQKPKKIT IKGSDGHLYV
MMCKPKDDLR KDCRLMEFTT IVNKFLRKDP EARKRQLHIR TYTVIPLNEE CGIIEWVNNT
SGLQYILRKL YREKGLQISN RELKNHIPAL QAPLERKLEL FKMLLNLHPS VFYEWFLRTF
PDPTAWYNSR LAYARTSAVM DMVGYILGLG DRHGENILMD STTGDCVHVD FNCLFNKGET
FEWPERVPFR LTNNMVKAMG PMGYEGIFRQ ACEVTLKILR NQMDPLMSVL KPFIYDPLVE
WQKLTKGQRS HQVSSGEITN EQAMTHVQMI EHRMRGIHAS KTKPRGLPLS VEGQVNYLIH
EATNEKLLCQ MYIGWAPYL
//
