ID A0A0L8I196_OCTBM Unreviewed; 483 AA.
AC A0A0L8I196;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit {ECO:0000256|ARBA:ARBA00031109};
DE AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
GN ORFNames=OCBIM_22000518mg {ECO:0000313|EMBL:KOF94825.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF94825.1};
RN [1] {ECO:0000313|EMBL:KOF94825.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF94825.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF94825.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00029358};
CC -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC {ECO:0000256|ARBA:ARBA00025711}.
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DR EMBL; KQ416865; KOF94825.1; -; Genomic_DNA.
DR RefSeq; XP_014767901.1; XM_014912415.1.
DR AlphaFoldDB; A0A0L8I196; -.
DR STRING; 37653.A0A0L8I196; -.
DR EnsemblMetazoa; Ocbimv22000518m; Ocbimv22000518m.p; Ocbimv22000518m.g.
DR EnsemblMetazoa; XM_014912415.1; XP_014767901.1; LOC106867520.
DR GeneID; 106867520; -.
DR KEGG; obi:106867520; -.
DR OMA; AYLPIMS; -.
DR OrthoDB; 5474505at2759; -.
DR UniPathway; UPA00363; UER00861.
DR GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR045190; MCCB/AccD1-like.
DR PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR22855:SF13; METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
PE 4: Predicted;
FT DOMAIN 1..226
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 226..471
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 483 AA; 52090 MW; 00C84AC427D66338 CRC64;
MLPRDRINTL LDSGSPFLEL SQLAGYELYG NEEVPAGGII CGIGRVSGVE CMIVANDPTV
KGGSYYPITV KKHVRAQEIA QQNRLPCIYL VDSGGANLPR QANVFPDRDH FGRIFFNQAN
MSSLGIPQIA IVLGSCTAGG AYVPAMADES VIVRKQGTIF LAGPPLVKAA TGEEVSAENL
GGADLHCGKS GVTDHYAQDD GHALHIARRI VSNLNYVKKP NVTITEVEEP VHPADELYGL
VGSNLKKSFD VREVIARTVD GSRFDEFKSM YGDSIVTGFA RIWGYPVGIL GNNGVLFSES
ALKATHFIEL CCQRGIPLLF LQNITGFMVG REAEIGGIAK NGAKMVTAVA CAKVPKITVI
IGGSYGAGNY GMCGRAYSPR FLYMWPNARI SVMGGEQAAN VLAQITREQK KREGKEWSTE
EEEALKAPVI QKYEAEGSPY FSSARLWDDG VIDPVDTRTV IGLSLSAALN SPVMPTNFGI
FRM
//
