ID A0A0L8IDY7_OCTBM Unreviewed; 672 AA.
AC A0A0L8IDY7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22012327mg {ECO:0000313|EMBL:KOF99703.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF99703.1};
RN [1] {ECO:0000313|EMBL:KOF99703.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF99703.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF99703.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ415907; KOF99703.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8IDY7; -.
DR STRING; 37653.A0A0L8IDY7; -.
DR EnsemblMetazoa; Ocbimv22012327m; Ocbimv22012327m.p; Ocbimv22012327m.g.
DR OMA; DAHFREW; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00153; RA_RalGDS_like; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF312; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 203..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..189
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 217..484
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 562..653
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
SQ SEQUENCE 672 AA; 77321 MW; 6B9A9248F79DF936 CRC64;
MKIHIARKED ASKFWSEERE NGAVYNIYLK KVTYKSATDL EYEQSREFSH LMWETHKVRV
IKSGTLSKLV ESLVTVKGEM DSCYVNVFLA TYRTFATPHQ VLNLLIERYK ILKSEDKEKT
ELHDVQLKTI KSVISVWLDT YPEDFREDPD YPCLQMLEKF AQECMEDRDL AFRAKHKEER
FRKEAQQNRV KFKYKIVQLT QKVNAVVVTI MMDGGGAGVA MMVLMMMMVK YLFRKVIPHH
CLGAVWARRD RKSGREPPTV LATIEQFNRV SLRVTATILK QSERKAARVR VITKWIEIAM
ELRDLKNFSS LKAIISGLQA HPVYRLRKTW AAVPKETLAL FEELSELCSE ENNQIASREI
LMKEATAKFP DLECSNKTLK KKNMLKRQSW IEKGIIQGTV PYLGTFLTDL TMMDTAMPDI
TENIQINFEK KRKEFEVLAQ IKLLQLAAQI YHFKDDTQFW LWFDAIRVYD ENESHDLSCI
IEPPTDEVKI KKKSASLGHK PSKWDTAKLP QFVCTHDDGL SVTSLSDSPV SVSTGPLISH
SSSASSLLSS DSDVTSPYRF PDSCIIKVSV QTEESSGTHV YKSIMLSNTD HTHTVIKKSL
EKYSIERCQE DFTLSQILPD KELLIPSKAN VFYAMNNNNP NSDLNFVVRT KSCQEALSKK
RKSRGKLKKL SL
//
