ID A0A0M0JRG2_9EUKA Unreviewed; 837 AA.
AC A0A0M0JRG2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Ubiquitin carboxyl-terminal hydrolase 26-like protein {ECO:0000313|EMBL:KOO28887.1};
GN ORFNames=Ctob_004573 {ECO:0000313|EMBL:KOO28887.1};
OS Chrysochromulina tobinii.
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Prymnesiales;
OC Chrysochromulinaceae; Chrysochromulina.
OX NCBI_TaxID=1460289 {ECO:0000313|EMBL:KOO28887.1, ECO:0000313|Proteomes:UP000037460};
RN [1] {ECO:0000313|Proteomes:UP000037460}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP291 {ECO:0000313|Proteomes:UP000037460};
RX PubMed=26397803; DOI=10.1371/journal.pgen.1005469;
RA Hovde B.T., Deodato C.R., Hunsperger H.M., Ryken S.A., Yost W., Jha R.K.,
RA Patterson J., Monnat R.J. Jr., Barlow S.B., Starkenburg S.R.,
RA Cattolico R.A.;
RT "Genome Sequence and Transcriptome Analyses of Chrysochromulina tobin:
RT Metabolic Tools for Enhanced Algal Fitness in the Prominent Order
RT Prymnesiales (Haptophyceae).";
RL PLoS Genet. 11:e1005469-e1005469(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOO28887.1}.
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DR EMBL; JWZX01002498; KOO28887.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M0JRG2; -.
DR OrthoDB; 307371at2759; -.
DR Proteomes; UP000037460; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd01795; Ubl_USP48; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR044743; Ubl_USP48.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF722; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR Pfam; PF00443; UCH; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:KOO28887.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000037460};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 83..429
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT DOMAIN 716..775
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 118..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 90685 MW; 7B4BADF900BDE5CC CRC64;
MSGKKVRRDA MPMPQLSDAK ARQQYIYGLA TQAAAKKQKS AADPTDLQAV EAAAKKAAKD
ADAKLLFGLE PRDKVRTDAT AGTGLRNLGA TCYMNSLLQC LHMNVGFRRG IYKWAGGAGA
GGGSSGQPPP PEAAAAAAST GSSRRPEEVR ADEVCRQLQL LFANLQHSDS ACYDPAALTS
ALSLDVSVQQ DASEFCKLLL SFLEEQLKLS PEPAIQTLVQ DHFRGSFCYH TQCCTCRTPS
DSSSICFPFY ELDLNVRPTL QQALDEYIAV EHLDGSNQYE CIHCKGRRDA TRQIAIRQLP
PVLCLQLKRF VYDPNKDAKK KSPAARWLTV NDELVTEEDF DPAKAATKPK PNGVTLLKQS
APCDGRLFAS HEAYMLMYTR DDVIAEAQAT HAEVQAPATV REAVHAANVA LRAATEKYQD
ALCAHTERLT ARQTLIDELR PILRSDGHDG RWIESRWLQA CLTLGPRGTT DELGPIRNQF
IECCHGGAAD PKHVSTGAMK LISVAAWQKL LGLFGGGPEL LATGCVECAD AEWERRQLEM
AKEAHKAALA VALNSASSSL TKHASVEANG GDGGVPHDDY YYVPRLTGSK WVRWLSEGQR
DATRELFCPH DKLLRLEAHA RTIGAEAWGH LFALFPDSIP ILVEAVGRGD GDGRLVECAA
CLVSECEREA AKADEKMSAK LSAKSEIASR SAQRQRLGRL LQEDGRLDPD VLRSKLSVRA
SSSINVLNLK LRIYQATEWS PSQQRLFIDG DELLNDEQTL SDAGVLPNSF IHVYIDTSRV
AEMPAIEEAF GSASGGKPRA PEDGFAGSAL VSASLGASRS AAAAGESDAS ANVMDLT
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