ID A0A0M0JXV3_9EUKA Unreviewed; 1165 AA.
AC A0A0M0JXV3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Polycystic kidney disease protein-2 {ECO:0000313|EMBL:KOO31405.1};
GN ORFNames=Ctob_001823 {ECO:0000313|EMBL:KOO31405.1};
OS Chrysochromulina tobinii.
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Prymnesiales;
OC Chrysochromulinaceae; Chrysochromulina.
OX NCBI_TaxID=1460289 {ECO:0000313|EMBL:KOO31405.1, ECO:0000313|Proteomes:UP000037460};
RN [1] {ECO:0000313|Proteomes:UP000037460}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP291 {ECO:0000313|Proteomes:UP000037460};
RX PubMed=26397803; DOI=10.1371/journal.pgen.1005469;
RA Hovde B.T., Deodato C.R., Hunsperger H.M., Ryken S.A., Yost W., Jha R.K.,
RA Patterson J., Monnat R.J. Jr., Barlow S.B., Starkenburg S.R.,
RA Cattolico R.A.;
RT "Genome Sequence and Transcriptome Analyses of Chrysochromulina tobin:
RT Metabolic Tools for Enhanced Algal Fitness in the Prominent Order
RT Prymnesiales (Haptophyceae).";
RL PLoS Genet. 11:e1005469-e1005469(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOO31405.1}.
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DR EMBL; JWZX01002021; KOO31405.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M0JXV3; -.
DR OrthoDB; 3080916at2759; -.
DR Proteomes; UP000037460; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000037460};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 573..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 768..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..128
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 279..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 904..937
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1016..1094
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1165 AA; 130772 MW; 5CC37C2A9C1A1F46 CRC64;
MADGAQGIWG RQHGHGLARL ANAGGLVAAA AASKKGGSMV PLVKHATKKA KIAKPPDATA
LPAARAAAER LAARNKRIQK VALFSPRSGK PTNDPVLLKR VFQTFDRDGT GAVSLAEMAA
MLRVLKIRIT QRELDRICKS VDDGSGELDF EEFYRALQMI RNLQVTESLF DKVMNFVNTV
GFQTILYISY VLVFQEFAGT VRTKEEYYVH KAVTDTLLAR PFGHNHLTFM QIKRIGDIYK
WGDQVLWPGL FGGMGPCNAS VGVRDTLANK RCQDDAWPDG EGPLSMYPKQ TPTNNMRGPT
PADLFELVRR MDKLDWSEGI TFRVARTRDQ PCDPDLPWPR TMRPRLRTER YVPGNVTFVE
PPCPPELGFG TGSAVPYGVN FSHPGEPMVH PFYWYSATEL GADPRGLSSA NLVALTREPY
ESAGYVALVI PFFSDVLLPN QVGSFEEVED FRTSAVNATN DRHVRYYCVR LSHNGAQVRQ
LCDPTSNLRT NDGELTGVVR AAVEELWGDL RRGHYLDALS RVLTITLQFN SNHVGVRYRL
TLVLELTSLG TVLPSYHIET MATHPQKLED LSFYSRVSLF TVVMFVLLEL VRMARMGQKG
FANLLNYFTD MWNFADWLNF LIFGLTYWQV LIVERLLKAR DCEGSYLCRE LGYFDDWQLM
GEYRWLKELF SFNLCVQLLK VAKYSSALIP KMSIATDTLR HAMVDMLFFA LTVGITIFSF
SSLLWVILGP VVNDFYDQVP AMISVMSAFF IDFDFVEAMQ RSSGYFSVIL MLCYLFVAVF
ILLTLFLSIL AEAQVKVRLD MLEQEANDPA FSSFGTLADL WMVFEKGVDR ILKEFEVKNP
WPDTPPESED EAEVTPRGAL GLDYDPPHDW EAVGDLRNDV SVLHGGLDQL GSLVFGTVDQ
LDEQKRLEAL AVAARRAARA AERAAIEREA AEAATEERAA FQRRRRRGEV GVESEEVHAA
AEEAAEKAAA AAREKAEARL AATHRGVAAS IVESLLDATI AAVQARAARR AREATAHEAN
DELRRARELM RSLAERHLAT LDRLEQRFFA DDFTRRKEQW RKLQMHRQAL ASEGDEAKEE
LERLDAQSIR AEDRLDKLDR WQHRHSGLLR ASAAVEVHAD GTYDVKVPGV GLHQRVPHAD
LRLRDGGGML PILALERTVP VAIRE
//
