ID A0A0M0LS33_9EUKA Unreviewed; 537 AA.
AC A0A0M0LS33;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 22-FEB-2023, entry version 20.
DE SubName: Full=24-dehydrocholesterol reductase {ECO:0000313|EMBL:KOO53717.1};
GN ORFNames=Ctob_012638 {ECO:0000313|EMBL:KOO53717.1};
OS Chrysochromulina tobinii.
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Prymnesiales;
OC Chrysochromulinaceae; Chrysochromulina.
OX NCBI_TaxID=1460289 {ECO:0000313|EMBL:KOO53717.1, ECO:0000313|Proteomes:UP000037460};
RN [1] {ECO:0000313|Proteomes:UP000037460}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP291 {ECO:0000313|Proteomes:UP000037460};
RX PubMed=26397803; DOI=10.1371/journal.pgen.1005469;
RA Hovde B.T., Deodato C.R., Hunsperger H.M., Ryken S.A., Yost W., Jha R.K.,
RA Patterson J., Monnat R.J. Jr., Barlow S.B., Starkenburg S.R.,
RA Cattolico R.A.;
RT "Genome Sequence and Transcriptome Analyses of Chrysochromulina tobin:
RT Metabolic Tools for Enhanced Algal Fitness in the Prominent Order
RT Prymnesiales (Haptophyceae).";
RL PLoS Genet. 11:e1005469-e1005469(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOO53717.1}.
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DR EMBL; JWZX01000102; KOO53717.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M0LS33; -.
DR OrthoDB; 5486440at2759; -.
DR Proteomes; UP000037460; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050614; F:delta24-sterol reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR Gene3D; 3.30.465.10; -; 1.
DR InterPro; IPR040165; Diminuto-like.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR10801; 24-DEHYDROCHOLESTEROL REDUCTASE; 1.
DR PANTHER; PTHR10801:SF0; DELTA(24)-STEROL REDUCTASE; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000037460};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..232
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 537 AA; 60849 MW; 93E2F26AC7D9430D CRC64;
MCNAPATSIG KKPPLGERIF TYVMTEYRSL IVVLFALPLS MMWDFLLYLR WQWAAYTKVP
VLHATRVERV VEQIKARPKG MRMCTGRPGW QCMSLSYRNY KSSMHQIDAV VDMIDIVSLD
LKSDNMSITV EPLVTTGQLT GALLHLGYTL PVVPEMDDLT VGGLVNGTGI ESSSHLEGLF
HEQCLAYEVC LADGTVVNAT PDNEYSDLFH AIPWSYGTLG MLLSVKIRVV PCKKYVQVTY
TPHRDRTAGV AHFAKLAGAG KAAPSFVEAL AFSPTELVVM AGEMVDEAPT GVNHLGHWYK
PWFYKHCESK LHDGKPSVEY IPLRDYYHRH TKSMFWEMEL FLPVGNHPIA RVLLGWLLPP
KVSFMKLTQT EMTRKLMEET HLAQDFMFPM DTLEECIALS DDLFDRFYPL WLCPHVHRPM
PGTIMPDPVR PGPDGSQMYV DLGVYGLPTC VKERPTCHGF DMIKSMRTFE ARMRQIGGVE
MLYADIFCTK EEFESMYPHK GYRELRAKYG AVGAFPEVYD KINNPDKKAK ATVTKSK
//
