ID A0A0M2K1N1_9MYCO Unreviewed; 339 AA.
AC A0A0M2K1N1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=2-oxoisovalerate dehydrogenase {ECO:0000313|EMBL:KKF01103.1};
DE SubName: Full=Alpha-ketoacid dehydrogenase subunit beta {ECO:0000313|EMBL:TDL03309.1};
GN ORFNames=EUA04_25615 {ECO:0000313|EMBL:TDL03309.1}, WN67_15375
GN {ECO:0000313|EMBL:KKF01103.1};
OS Mycolicibacterium obuense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1807 {ECO:0000313|EMBL:KKF01103.1, ECO:0000313|Proteomes:UP000034150};
RN [1] {ECO:0000313|EMBL:KKF01103.1, ECO:0000313|Proteomes:UP000034150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UC1 {ECO:0000313|EMBL:KKF01103.1,
RC ECO:0000313|Proteomes:UP000034150};
RA Greninger A.L., Cunningham G., Chiu C.Y., Miller S.;
RT "Genome sequence of Mycobacterium obuense UC1.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TDL03309.1, ECO:0000313|Proteomes:UP000294952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=22DIII {ECO:0000313|EMBL:TDL03309.1,
RC ECO:0000313|Proteomes:UP000294952};
RA Tiago I., Alarico S., Pereira S.G., Coelho C., Maranha A., Empadinhas N.;
RT "High-quality-draft genome sequences of five non-tuberculosis
RT mycobacteriaceae isolated from a nosocomial environment.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKF01103.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LAUZ02000018; KKF01103.1; -; Genomic_DNA.
DR EMBL; SDLP01000012; TDL03309.1; -; Genomic_DNA.
DR RefSeq; WP_046363909.1; NZ_SDLP01000012.1.
DR STRING; 1807.MOBUDSM44075_03076; -.
DR PATRIC; fig|1807.13.peg.2050; -.
DR OrthoDB; 4009369at2; -.
DR Proteomes; UP000034150; Unassembled WGS sequence.
DR Proteomes; UP000294952; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
FT DOMAIN 21..196
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 339 AA; 37151 MW; B72E52290795B024 CRC64;
MTQLIERPFG FDDDVPEVEN LSMAQAINRA LSDAMLADDR VVVFGEDVAT LGGVFRVTDG
LARRFGDSRC FDTPLAESAI VGIAIGMAIR GFVPVPEIQF DGFAAPAFDQ IVSHLAKYRM
RTHGDVDMPV TIRIPSFGGI GAVEHHSEST ETYWLHAAGL KVVVPSTPAD AYWLLRYAIA
ERDPVIFLEP KRRYWAREPV DTRNPAEPLG RAVIRRAGRD VSVITYGPLV ATALTAAETA
TASVEVIDLR TLNPLDMATV AASVRRTGRA VVMHEGSRTL GFGAELAARI QEECFYELEA
PVLRATGFDT PYPPARLERL WLPGVDRLLD CVDDAMSRP
//
