ID A0A0M2K2A4_9MYCO Unreviewed; 258 AA.
AC A0A0M2K2A4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Enoyl-CoA hydratase {ECO:0000313|EMBL:KKF03033.1};
DE EC=4.2.1.17 {ECO:0000313|EMBL:KKF03033.1};
GN ORFNames=EUA04_18280 {ECO:0000313|EMBL:TDL06649.1}, WN67_05220
GN {ECO:0000313|EMBL:KKF03033.1};
OS Mycolicibacterium obuense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1807 {ECO:0000313|EMBL:KKF03033.1, ECO:0000313|Proteomes:UP000034150};
RN [1] {ECO:0000313|EMBL:KKF03033.1, ECO:0000313|Proteomes:UP000034150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UC1 {ECO:0000313|EMBL:KKF03033.1,
RC ECO:0000313|Proteomes:UP000034150};
RA Greninger A.L., Cunningham G., Chiu C.Y., Miller S.;
RT "Genome sequence of Mycobacterium obuense UC1.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TDL06649.1, ECO:0000313|Proteomes:UP000294952}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=22DIII {ECO:0000313|EMBL:TDL06649.1,
RC ECO:0000313|Proteomes:UP000294952};
RA Tiago I., Alarico S., Pereira S.G., Coelho C., Maranha A., Empadinhas N.;
RT "High-quality-draft genome sequences of five non-tuberculosis
RT mycobacteriaceae isolated from a nosocomial environment.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Could possibly oxidize fatty acids using specific components.
CC {ECO:0000256|ARBA:ARBA00002994}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O;
CC Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:58856; EC=4.2.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00023709};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O;
CC Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
CC ChEBI:CHEBI:137480; EC=4.2.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00023717};
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254, ECO:0000256|RuleBase:RU003707}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKF03033.1}.
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DR EMBL; LAUZ02000002; KKF03033.1; -; Genomic_DNA.
DR EMBL; SDLP01000005; TDL06649.1; -; Genomic_DNA.
DR RefSeq; WP_046362022.1; NZ_SDLP01000005.1.
DR STRING; 1807.MOBUDSM44075_01917; -.
DR PATRIC; fig|1807.13.peg.365; -.
DR OrthoDB; 8452484at2; -.
DR Proteomes; UP000034150; Unassembled WGS sequence.
DR Proteomes; UP000294952; Unassembled WGS sequence.
DR GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.12.10; Lyase 2-enoyl-coa Hydratase, Chain A, domain 2; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR PANTHER; PTHR11941:SF54; ENOYL-COA HYDRATASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11941; ENOYL-COA HYDRATASE-RELATED; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:KKF03033.1}.
SQ SEQUENCE 258 AA; 27139 MW; 814B5B48A0433194 CRC64;
MTDHETILVT REGRVATITL NRPKALNALN SQVMNDVTSA AAELDADPGI GAIVLTGNEK
AFAAGADIKE MANLSFAEVF SSDFFAAWGN FAATRTPTIA AVAGYALGGG CELAMMCDIL
IAADTAKFGQ PEIKLGVLPG MGGSQRLTRA IGKAKAMDLI LTGRTMGAEE AERAGLVSRV
VPADSLLEEA TATAQTIAGM SLSAARMAKE AVDRAFESTL AEGLLYERRL FHSAFATDDQ
TEGMAAFTEK RSPNFTHR
//
