ID   A0A0M2LSD4_9SPHN        Unreviewed;       481 AA.
AC   A0A0M2LSD4;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KKI18669.1};
GN   ORFNames=XM50_12325 {ECO:0000313|EMBL:KKI18669.1};
OS   Sphingomonas sp. Ag1.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=1642949 {ECO:0000313|EMBL:KKI18669.1, ECO:0000313|Proteomes:UP000033997};
RN   [1] {ECO:0000313|EMBL:KKI18669.1, ECO:0000313|Proteomes:UP000033997}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ag1 {ECO:0000313|EMBL:KKI18669.1,
RC   ECO:0000313|Proteomes:UP000033997};
RA   Pei D., Yu W., Kukutla P., Xu J.;
RT   "Draft Genome Sequences of Sphingomonas sp. Ag1 from Mosquito Anopheles
RT   gambiae.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKI18669.1}.
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DR   EMBL; LAZX01000093; KKI18669.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M2LSD4; -.
DR   STRING; 1642949.XM50_12325; -.
DR   PATRIC; fig|1642949.3.peg.1625; -.
DR   OrthoDB; 462203at2; -.
DR   Proteomes; UP000033997; Unassembled WGS sequence.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006905; Flavin_halogenase.
DR   InterPro; IPR033856; Trp_halogen.
DR   PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR   PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR   Pfam; PF04820; Trp_halogenase; 1.
DR   PIRSF; PIRSF011396; Trp_halogenase; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2}.
FT   ACT_SITE        60
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT   BINDING         60
FT                   /ligand="7-chloro-L-tryptophan"
FT                   /ligand_id="ChEBI:CHEBI:58713"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         309
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         318
FT                   /ligand="L-tryptophan"
FT                   /ligand_id="ChEBI:CHEBI:57912"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         322
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ   SEQUENCE   481 AA;  53167 MW;  B1495831F22BBCAA CRC64;
     MAAAAIARTM GRAAQVTLVE SEAIGTIGVG ESTIPPIVGF NRLLGINEAE FMAATNATFK
     LGIVFDGWRN GTDRYVHAFG LTGKDHWAAG FQHFWLAGRA KGHQAPFGDY SVELQAALAG
     KFAHLPDDRL NYAYQLDSGL YAKFLRGMAE RDGAVRIEGK IATVQLDGDS GDIAALVLED
     GTAIAGDLFL DCTGFRALLI EGALHAGFDD WTHWLPCDSA IAVQTASVGP AVPYTRAMAH
     DAGWQWRIPL QHRVGNGIVW CSRYLSREDA LERLLGNVEG EVLTQPNHLR FTTGVRRRQW
     HRNCVAVGLS GGFMEPLEST SIHLIQRAVL RLIRMMPAAG PISPRDIAEF NDQQHADMVQ
     VRDFLILHYK ATDRRDSAFW RQCAAMPIPD SLEQKIELFR DTARVFRRNE ELFAEHSWLQ
     VLLGQGIEPH AWHPITGKLT DEELARLLQT LRAQVTRTVN GLPAHADYVA RYCAGARQSA
     A
//