ID A0A0M2S5K2_9ACTN Unreviewed; 630 AA.
AC A0A0M2S5K2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase {ECO:0000256|ARBA:ARBA00012519};
DE EC=2.7.7.70 {ECO:0000256|ARBA:ARBA00012519};
GN ORFNames=LQ51_03490 {ECO:0000313|EMBL:KKK07274.1};
OS Micromonospora sp. HK10.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1538294 {ECO:0000313|EMBL:KKK07274.1, ECO:0000313|Proteomes:UP000034330};
RN [1] {ECO:0000313|EMBL:KKK07274.1, ECO:0000313|Proteomes:UP000034330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HK10 {ECO:0000313|EMBL:KKK07274.1,
RC ECO:0000313|Proteomes:UP000034330};
RA Talukdar M., Das D., Borah C., Deka Boruah H.P., Bora T.C., Singh A.K.;
RT "Draft genome sequence of Micromonospora HK10, isolated from Kaziranga
RT National park, Assam, India.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-
CC D-glycero-beta-D-manno-heptose + diphosphate; Xref=Rhea:RHEA:27465,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:59967, ChEBI:CHEBI:61593; EC=2.7.7.70;
CC Evidence={ECO:0000256|ARBA:ARBA00000534};
CC -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004713}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKK07274.1}.
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DR EMBL; JTGL01000024; KKK07274.1; -; Genomic_DNA.
DR RefSeq; WP_046566376.1; NZ_KQ058826.1.
DR AlphaFoldDB; A0A0M2S5K2; -.
DR STRING; 1538294.LQ51_03490; -.
DR PATRIC; fig|1538294.3.peg.3252; -.
DR HOGENOM; CLU_021150_2_1_11; -.
DR OrthoDB; 9802794at2; -.
DR UniPathway; UPA00958; -.
DR Proteomes; UP000034330; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1190.20; -; 2.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR011914; RfaE_dom_II.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR NCBIfam; TIGR02199; rfaE_dom_II; 1.
DR PANTHER; PTHR43793:SF2; BIFUNCTIONAL PROTEIN HLDE; 1.
DR PANTHER; PTHR43793; FAD SYNTHASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR Pfam; PF00294; PfkB; 2.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
DR PROSITE; PS00583; PFKB_KINASES_1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 23..123
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
FT DOMAIN 364..445
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
FT DOMAIN 488..583
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT REGION 235..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 64898 MW; 45AEB26F95F84495 CRC64;
MAGAAAEERR LATVVESWLG RPVLVVGDAM LDEWRFAESD RLCREAPAPV LTLRRRISAA
GGAANTAVNV AALGGRAALV APVGADVAGD ELHDCLDRAG VWDRTVNQPG RPTPVKRRML
AGNQILLRED SGDPDDALDD DGVARLLTAL HCATEELHAA AHGQPLTLVV CDYGLGALPG
GVRAWLVANR DRYATVALDA HDLADWRGLN PTVVTPSFAE ATRLLARAAA GFNGAGHPPR
RVDGLHLDHQ DDPADGPSEL VVGAAPGGAG EPAPVPDPLR DGSSLAMGSA PAGHRPPGTP
HPTSGTAPAA AGPTGEPTPG EERVALTGDG LSVTGTGVTV NAEVGEGVDR AVLAQSRLDE
LRAHTGADVV AVTLDTEGAV VGGADGEPRR SHSTPVPASH AVGAGDAYLA AMTLALAAEA
SLPTAAQLAQ LAATITVSDT GTCVCRREDL LDALGTGPEE GDHPTLVGAA ELGAIVTEHR
RAGRSIVFTN GCFDVLHPGH VRYLTQARAL GDLLVVAVNS DGSVRRLKGP DRPVNPVEDR
AALLAALECV DHVVVFEEDS PAGLIEAVRP DVYVKGGDYP PEMVPEAPLV RRLGGQVRTL
GYVPDRSTSA IIDRIRAQSV TPPVGEGRSA
//
