ID   A0A0M3HVT9_ASCLU        Unreviewed;       226 AA.
AC   A0A0M3HVT9;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 {ECO:0000256|ARBA:ARBA00040793};
DE            EC=3.1.7.2 {ECO:0000256|ARBA:ARBA00024387};
DE   AltName: Full=Metazoan SpoT homolog 1 {ECO:0000256|ARBA:ARBA00041464};
DE   AltName: Full=Penta-phosphate guanosine-3'-pyrophosphohydrolase {ECO:0000256|ARBA:ARBA00041770};
OS   Ascaris lumbricoides (Giant roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6252 {ECO:0000313|Proteomes:UP000036681, ECO:0000313|WBParaSite:ALUE_0000713401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ALUE_0000713401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: ppGpp hydrolyzing enzyme involved in starvation response.
CC       {ECO:0000256|ARBA:ARBA00037781}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP +
CC         H(+); Xref=Rhea:RHEA:14253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:58189, ChEBI:CHEBI:77828; EC=3.1.7.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00024273};
CC   -!- SIMILARITY: Belongs to the MESH1 family.
CC       {ECO:0000256|ARBA:ARBA00038354}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A0M3HVT9; -.
DR   WBParaSite; ALUE_0000713401-mRNA-1; ALUE_0000713401-mRNA-1; ALUE_0000713401.
DR   Proteomes; UP000036681; Unplaced.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   PANTHER; PTHR46246; GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1; 1.
DR   PANTHER; PTHR46246:SF1; GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
FT   DOMAIN          78..173
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
SQ   SEQUENCE   226 AA;  25761 MW;  E50C18670ACA0B8A CRC64;
     MAEDDVLNKS CPPPYSQIYP NVAREDVSAR LDNNERHEAS EESASCVFNG VELIVKASDF
     AARKHRHQRR KDRQQTPYIN HPIGVAYILT NEAKVCDPST IAAAILHDTV EDTDTTLDEI
     REIFGQEIHD IVAECCDDKT QPREVRKQAQ IDNASKHSHK AKLVHLADKL YNLRDLERGT
     PVGWDGNRVR EYFVWSKAVV TQLKGTNEAL ELALDEIIER KLHQIR
//