ID A0A0M3IZ10_ANISI Unreviewed; 827 AA.
AC A0A0M3IZ10;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 {ECO:0000313|WBParaSite:ASIM_0000049001-mRNA-1};
GN ORFNames=ASIM_LOCUS393 {ECO:0000313|EMBL:VDK17663.1};
OS Anisakis simplex (Herring worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC Anisakis simplex complex.
OX NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0000049001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ASIM_0000049001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK17663.1, ECO:0000313|Proteomes:UP000267096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYRR01000226; VDK17663.1; -; Genomic_DNA.
DR WBParaSite; ASIM_0000049001-mRNA-1; ASIM_0000049001-mRNA-1; ASIM_0000049001.
DR Proteomes; UP000036680; Unplaced.
DR Proteomes; UP000267096; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45854:SF3; ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000267096};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 384..477
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 509..631
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 291..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 93714 MW; 52E5462C70E88B74 CRC64;
MASTSHNNCT DNLISSFTAS LKSDLDSPVT SNFGNHIADY HTQVQNIAEQ IENDASEFER
LRKISKDIED GIGTLAKQLN AFAQVSKELA EKWTTKSEND TESDAAIALL KMELFMRNES
ELMNGQLRNW HNNMVHPLDL LVKSPNELKI KNVDKACREY DSKFVKTENE TRKIAKQCGY
TRSQLSHGEL AEQLSKERIF VEYELCKFML GADSFEDKRG AQLFRHFMEL FRSQDIYYKE
RLKLNEHFRS DLERLEERMQ ARNATRCQQR NALFDLKTCL ETHSEIIRNA SGNRQMSRAD
SLLNRSSLSQ STISGSTDKS KQKLISSSAN KTAQSQSNGS NADKSMLNQS AHHKVALTPM
NQVPLNMSTS VHQQQQQQSS NDERIDLNGY LFKKTNNKLH KLWQKRRCRL HDGYFCISHS
DESLAPVTMD LRISDCKPSA DDPKAFDFYC RDRTYHLQAE TEALLQQWIL ALKQEMERVK
SKMLTSDDQT SSSVWLNQNA STERDTNDQL CINTLKALPG NLRCADCSST KQVEWLSNIG
SLVCIACSGV HRELGVHISR IHSIDLDVIS AVEYLVPLAT GNTLINRIFE YNETSCAQWK
PTAECTRSDR QRFIQYKYRD RCYIEKVEQA DRLFCDALRE LDVEKAYRAL LSPSLTSLPF
EVNGPFQTLI QKTKAMSLVI AQLVVQLRIG LPSLESILVD CVNNANIDLL IILLQSHAFN
SLLSNGFSLE PLERLAHKLG HHNIVELLCS VQSPERTLFK QFTIPALLIS QASQSDSLSA
SSSSSSHLPN TNAEVDLITT NEQNSAQTPS AQIDVLMRNG TTIPVER
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