ID   A0A0M3K6D4_ANISI        Unreviewed;       330 AA.
AC   A0A0M3K6D4;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:ASIM_0001652501-mRNA-1};
OS   Anisakis simplex (Herring worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC   Anisakis simplex complex.
OX   NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001652501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ASIM_0001652501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000256|ARBA:ARBA00004305}.
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DR   AlphaFoldDB; A0A0M3K6D4; -.
DR   WBParaSite; ASIM_0001652501-mRNA-1; ASIM_0001652501-mRNA-1; ASIM_0001652501.
DR   Proteomes; UP000036680; Unplaced.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43561; -; 1.
DR   PANTHER; PTHR43561:SF1; HYDROXY-ACYL-COA DEHYDROGENASE; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128}.
FT   DOMAIN          55..238
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          241..328
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   330 AA;  35819 MW;  CAF4A10C8FC601C7 CRC64;
     LFKPSELLNK LVAEGKLGKK SGKGVANVFG ATLLPGVCVF QQLAPVSSIS SIRDVAIIGT
     GTMGCGIAQT VAESRMNVML VGRSEASLRR AVASINRFVK VIAKKELGLD KLAQDKLVDE
     VSKRITTTTS LQKAVAEADL VIEAVIERLD VKRELFQRIE SASKSRTLLA TNTSSLRLSE
     ISVNLQRKRN FGGLHFFNPV RMMKLLEVVR CAETSPETLK AFLAFGKALG KEAIECTDKP
     GFIVNRILVS SICESLKILE AGDASMKQID TAMRLGASHP MGPFQLISFI GVDTFKTILQ
     SLHEAYPDDA RFGCIELLNK MIDEGKFSAG
//