ID A0A0M4GC62_9BACI Unreviewed; 784 AA.
AC A0A0M4GC62;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|SMART:SM00849};
GN ORFNames=AM500_08875 {ECO:0000313|EMBL:ALC89875.1};
OS Bacillus sp. FJAT-18017.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=1705566 {ECO:0000313|EMBL:ALC89875.1, ECO:0000313|Proteomes:UP000060713};
RN [1] {ECO:0000313|EMBL:ALC89875.1, ECO:0000313|Proteomes:UP000060713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FJAT-18017 {ECO:0000313|EMBL:ALC89875.1,
RC ECO:0000313|Proteomes:UP000060713};
RA Liu B., Wang J., Zhu Y., Liu G., Chen Q., Chen Z., Lan J., Che J., Ge C.,
RA Shi H., Pan Z., Liu X.;
RT "Genome sequencing project for genomic taxonomy and phylogenomics of
RT Bacillus-like bacteria.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP012602; ALC89875.1; -; Genomic_DNA.
DR RefSeq; WP_053598888.1; NZ_CP012602.1.
DR AlphaFoldDB; A0A0M4GC62; -.
DR STRING; 1705566.AM500_08875; -.
DR PATRIC; fig|1705566.3.peg.1910; -.
DR Proteomes; UP000060713; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000060713};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 49..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 518..729
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 784 AA; 86261 MW; 0F4EDF5D56A0D041 CRC64;
MKTKAIFFVP SSILGVLAAT APSPLPMLTL FSAQILILKG MNKLKRNEVI LTLIVFTLFF
AVTKHTESAN QTILGKGERS LQLDFRSGAL IDGDSFKAFA VDLESGEELL VTYRIRSEAE
KEKLLSASFF GVSSILGGEL KIPPEARNPG GFDYRSYLRR QQVHWIFDSD TMPLEDARIR
KLTFYEMIGR VRETETKHLS ERLPKETARL VSALIFGEQS KIPENLEGAY TKLGISHLLA
ISGMQVSLLS GLVLYAGIRL GVAREKMAVL LILLLPVYAV LAGGSPSVIR SVIMASIMLT
IPLGSNRIGF GIVDALALSF LIFLFTSPYI LFNAGFQLSY AVTFVLVFSY QAFKEKELTG
LTFMITGTVI SQLAALPILL THFYTVPLIS ILANLVFIPL YSFIFSPVVY SFYILIALFG
SVPAWIGGAV NTIIIFSDNL ALALSKVPIQ LYPGKIPIFL LALYTIGVLT VFKLWEKIQL
WKKSLLILSV PFLILAVHSY ANTNFSKTGE ITIIDVGQGD SILISLPGGE GNYLIDAGGS
IVFEKKPWQE RVSSFDPGQD IVIPFLLARG IGKLDKLILT HGDQDHIGGA IAILEEVQVK
EIVMPHVEEK SKSEHDILAL AAEKQIKVTE VTKGDKWYAG GASFHILSPE KGNNKERNDN
SISLFTKLGG KSWFFSGDLE EQGEKSIMAN YPGLGIDVLK AGHHGSKTSS TEDFLTLYRP
KIILISAGAG NRFGHPHTET IQRFKELDTI IFRTDLHGAI TYTFYGGKGT FSTHLPYNAL
SNQE
//
