ID A0A0M4H5J3_9ACTO Unreviewed; 408 AA.
AC A0A0M4H5J3;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Thiamin pyrophosphokinase {ECO:0000313|EMBL:ALC99415.1};
GN ORFNames=AM609_07795 {ECO:0000313|EMBL:ALC99415.1};
OS Actinomyces sp. oral taxon 414.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=712122 {ECO:0000313|EMBL:ALC99415.1, ECO:0000313|Proteomes:UP000061022};
RN [1] {ECO:0000313|Proteomes:UP000061022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0588 {ECO:0000313|Proteomes:UP000061022};
RA Holder M.E., Ajami N.J., Petrosino J.F.;
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP012590; ALC99415.1; -; Genomic_DNA.
DR RefSeq; WP_053586822.1; NZ_CP012590.1.
DR AlphaFoldDB; A0A0M4H5J3; -.
DR STRING; 712122.AM609_07795; -.
DR KEGG; acq:AM609_07795; -.
DR PATRIC; fig|712122.3.peg.1756; -.
DR OrthoDB; 5169996at2; -.
DR Proteomes; UP000061022; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004788; F:thiamine diphosphokinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.10240; Thiamin pyrophosphokinase, catalytic domain; 1.
DR InterPro; IPR047795; Put_SteA-like.
DR InterPro; IPR022215; SteA-like_C.
DR InterPro; IPR007371; TPK_catalytic.
DR InterPro; IPR036759; TPK_catalytic_sf.
DR NCBIfam; NF040608; division_SteA; 1.
DR Pfam; PF12555; SteA-like_C; 1.
DR Pfam; PF04263; TPK_catalytic; 1.
DR SUPFAM; SSF63999; Thiamin pyrophosphokinase, catalytic domain; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ALC99415.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 354..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 214..247
FT /note="Thiamin pyrophosphokinase catalytic"
FT /evidence="ECO:0000259|Pfam:PF04263"
FT DOMAIN 341..391
FT /note="SteA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12555"
SQ SEQUENCE 408 AA; 43349 MW; EBECFD981B0EB0F4 CRC64;
MRNPFRKPSA PEPGRPVGVV RVDARTKKLA KRLRAGEFAV IDHADLDRVA AESLVECRPA
AVLNAAPSIS GRYPNLGPGI LIEAGVPLID DLGPDIMRLK EGQRVVLDLA EDSPDRGSVR
PVGSDEILAQ GTVQTAASVA TAMEEAKAGL AVQLEAFAAN TMEYMRGERD LLLNGVGMPD
VRTDMNGRHV LVVVRGYSYK EDLRALKPYI REYKPVIIGV DGGADAVLEA GFKPDMIVGD
MDSVSDRALG CGAEVVVHAY RDGRAPGLKR VEDLGVEHLV FAATGTSEDV AMLLADAAGA
ELIVALGTHA TLLEFLDKGR AGMSSTFLTR LKVGGRLIDA KGVSRLYRTR ISGWHLMVLA
LAGLIALFVA LAATPAGQTL LGLSGAMWDD IINFFRSILG LAPKTPSV
//
