ID   A0A0M6YHC2_9RHOB        Unreviewed;      1121 AA.
AC   A0A0M6YHC2;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE   AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN   Name=pcrA {ECO:0000313|EMBL:CTQ48903.1};
GN   ORFNames=JDO7802_00911 {ECO:0000313|EMBL:CTQ48903.1};
OS   Jannaschia donghaensis.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Jannaschia.
OX   NCBI_TaxID=420998 {ECO:0000313|EMBL:CTQ48903.1, ECO:0000313|Proteomes:UP000049222};
RN   [1] {ECO:0000313|EMBL:CTQ48903.1, ECO:0000313|Proteomes:UP000049222}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 7802 {ECO:0000313|EMBL:CTQ48903.1,
RC   ECO:0000313|Proteomes:UP000049222};
RA   Noorani M.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; CXSU01000011; CTQ48903.1; -; Genomic_DNA.
DR   RefSeq; WP_055083106.1; NZ_CXSU01000011.1.
DR   AlphaFoldDB; A0A0M6YHC2; -.
DR   STRING; 420998.JDO7802_00911; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000049222; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014151; DNA_helicase_AddA.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   NCBIfam; TIGR02784; addA_alphas; 1.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000049222}.
FT   DOMAIN          6..476
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          495..772
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          923..946
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         27..34
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1121 AA;  121264 MW;  8F9DD53DDC114442 CRC64;
     MSDFRPDAAT LAQIDAADPA GSVWLAANAG SGKTRVLTDR VAWLLLDGTA PEKILCLTFT
     KAAAGEMQNR LFGTLGEWAM LSDDALRAKI TRLGAGRGTI RTDQLMRART LFARAIEAPG
     GLKIQTIHAF CASLLRRFPL EAGVSPAFSE MDDTAKARLH AEVLDDMAVD PVLRPLLDRI
     ARRLTDGEPS QFLSAVAANR GGFRKTQTRE DLRVALGIED KSPDAVHDAA VTADDLTLID
     TVRAATRVET GVTMVRLTRL MDEAYTADPV TRFDLLCRAF LTQKHEPVKK PVSKAAGDIL
     GEDAVAEIVD LADRIADARA RIAAFDALAQ TEALHAFGPA FAAQVEARKQ ARGWLDFDDQ
     IDGARRLLST SDMAQWVLFK LDGGLDHILV DEAQDTSPAQ WDVIERLTQE FDAGASARSD
     VRRTVFIVGD RKQSIYGFQG ADLAAFDAKR DVFVERLAGS DAPMRDHALL HSFRSSPVIL
     ELVDEVFRDG GGIGAPPRHI AHKTNMPGRV DLWPAIPAQE ADLTDRVWYD PVDRPAANDA
     NVVLARRVAQ AIKAMIQDGT PVGPADARRP VKAGDILILL QRRGALFHHV VRECKAVGLD
     LAGADRLKLS TDMAAKDLIA ALTWAATPDD DLSLATVLRS PLGRTDEAGL FGLAHGRRKN
     QRLWDVLRDA ESDPDTTAML ADLLRIADIL RPYEVLQRIL IRHDGRRRLL ERLGAESGEA
     IDALLAQALA YEQLETPSLT GFLGWLASAD VDLKRQAGAG SIRVMSVHGA KGLEAPVVIL
     PETIKLKPRS IATIQRLDDG TPVWLPATEK RSPAMIDLVE NRNEADIAER DRLLYVAITR
     AENWLIVAAA EPKRKETGES WHDLITAAMT ARGAQFLNTA TGEILRLETG DWTPLGKVRG
     PVSTDGPASA DWLHARVAPP TKGATRIAPS GLPGAKALPG ETGLDGGDAM RRGTAIHALL
     EHLPLLPRAQ WDSRAAAMLA ADTDLRDLAV APLLAEAVSV LDTPDLAHVF APGTLAEVPF
     ALPESDTHPA MFGTMDRVIV APDRITVVDL KSNAIVPQTP ADTPVGILRQ MAAYRLAAQA
     IWPDRAISIQ ILWTKGPTLM EMPHTLATDL GPGIDRVDPP A
//