ID A0A0M8N4B6_9HYPO Unreviewed; 611 AA.
AC A0A0M8N4B6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Mannosyltransferase {ECO:0000256|RuleBase:RU363075};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU363075};
GN ORFNames=ESCO_001370 {ECO:0000313|EMBL:KOS19680.1};
OS Escovopsis weberi.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Escovopsis.
OX NCBI_TaxID=150374 {ECO:0000313|EMBL:KOS19680.1, ECO:0000313|Proteomes:UP000053831};
RN [1] {ECO:0000313|EMBL:KOS19680.1, ECO:0000313|Proteomes:UP000053831}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA de Man T.J., Stajich J.E., Kubicek C.P., Chenthamara K., Atanasova L.,
RA Druzhinina I.S., Birnbaum S., Barribeau S.M., Teiling C., Suen G.,
RA Currie C., Gerardo N.M.;
RT "The genome of the fungus Escovopsis weberi, a specialized disease agent of
RT ant agriculture.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-
CC anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI
CC during GPI precursor assembly. {ECO:0000256|ARBA:ARBA00024708}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU363075}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU363075}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 22 family. PIGB
CC subfamily. {ECO:0000256|ARBA:ARBA00006065}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOS19680.1}.
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DR EMBL; LGSR01000020; KOS19680.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M8N4B6; -.
DR STRING; 150374.A0A0M8N4B6; -.
DR OrthoDB; 37262at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000053831; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR005599; GPI_mannosylTrfase.
DR PANTHER; PTHR22760; GLYCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR22760:SF4; GPI MANNOSYLTRANSFERASE 3; 1.
DR Pfam; PF03901; Glyco_transf_22; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU363075};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU363075,
KW ECO:0000313|EMBL:KOS19680.1}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000053831};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KOS19680.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REGION 526..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 66861 MW; C1DF00267166633D CRC64;
MAKSTPATPP PRHAFHFRDV LLIRLINACS LATFFQPDEF FQVLEPAWHL AFGPDSGAWL
TWEWHHQLRS SLHPLLFSGA YLLADRLAAL LPASDSLRAA AILLAPRILQ AVIAALGDWF
TFKLARRIFS PDETVPLVAL LLQLLSPWQW YCSTRTFSNS LEATLTENPK PPPLLHHAAA
LRALRASLCL AALAAVLRPT NVLLWTPLAL AALPRALASP RDALLLAREA VLAAAAVLAA
AALADRWFFA RWTFPPWNWL AFNVSRDLAV FYGRNPWHYY LLQGLPLLCT TSLPFALPAL
LRPAAAVAGI GNENENENEN ANANGNGSGN LRSPAQAVAL ASLARTVAVS VAALSLISHK
EVRFIYPLLP ILSILSAPRA ASFFIAISPS SPSPSPSPSS KAKAKAKAPR RIRLAHKPLL
ALALALNALI AGYLSFLHQP APLSVLAFLR THSSGPAEDL FALFLTPCHS TPWRSHLLYP
SLSARALTCH PPLHTAPNSP ARLAYRDEAD RFYDDPLLFL RTELFGPQTP SNNTSNSDNT
SSSNTNNAAP LRPRFVIAFE GVEPWLHAFL ATDEGKALGW RPRRAWTGFN GFANEDWRRR
GALVVWDTGL Y
//
