ID   A0A0M8SEC7_9ACTN        Unreviewed;       780 AA.
AC   A0A0M8SEC7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Probable phosphoketolase {ECO:0000256|HAMAP-Rule:MF_01403};
DE            EC=4.1.2.- {ECO:0000256|HAMAP-Rule:MF_01403};
GN   ORFNames=ADK54_42220 {ECO:0000313|EMBL:KOU33464.1};
OS   Streptomyces sp. WM6378.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1415557 {ECO:0000313|EMBL:KOU33464.1, ECO:0000313|Proteomes:UP000037774};
RN   [1] {ECO:0000313|Proteomes:UP000037774}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM6378 {ECO:0000313|Proteomes:UP000037774};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964,
CC         ECO:0000256|HAMAP-Rule:MF_01403};
CC   -!- SIMILARITY: Belongs to the XFP family. {ECO:0000256|ARBA:ARBA00005623,
CC       ECO:0000256|HAMAP-Rule:MF_01403}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOU33464.1}.
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DR   EMBL; LGDD01000358; KOU33464.1; -; Genomic_DNA.
DR   RefSeq; WP_053731151.1; NZ_LGDD01000358.1.
DR   AlphaFoldDB; A0A0M8SEC7; -.
DR   PATRIC; fig|1415557.3.peg.9317; -.
DR   OrthoDB; 9768449at2; -.
DR   Proteomes; UP000037774; Unassembled WGS sequence.
DR   GO; GO:0016832; F:aldehyde-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd02011; TPP_PK; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   HAMAP; MF_01403; Phosphoketolase; 1.
DR   InterPro; IPR023962; Phosphoketolase.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005593; Xul5P/Fru6P_PKetolase.
DR   InterPro; IPR018969; Xul5P/Fru6P_PKetolase_C.
DR   InterPro; IPR019790; Xul5P/Fru6P_PKetolase_CS.
DR   InterPro; IPR018970; Xul5P/Fru6P_PKetolase_N.
DR   InterPro; IPR019789; Xul5P/Fru6P_PKetolase_ThDP_BS.
DR   PANTHER; PTHR31273; PHOSPHOKETOLASE-RELATED; 1.
DR   PANTHER; PTHR31273:SF0; PHOSPHOKETOLASE-RELATED; 1.
DR   Pfam; PF03894; XFP; 1.
DR   Pfam; PF09363; XFP_C; 1.
DR   Pfam; PF09364; XFP_N; 1.
DR   PIRSF; PIRSF017245; Phosphoketolase; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   PROSITE; PS60002; PHOSPHOKETOLASE_1; 1.
DR   PROSITE; PS60003; PHOSPHOKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_01403};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052, ECO:0000256|HAMAP-
KW   Rule:MF_01403}.
FT   DOMAIN          7..359
FT                   /note="Xylulose 5-phosphate/Fructose 6-phosphate
FT                   phosphoketolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09364"
FT   DOMAIN          576..778
FT                   /note="Xylulose 5-phosphate/Fructose 6-phosphate
FT                   phosphoketolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09363"
SQ   SEQUENCE   780 AA;  86095 MW;  EC1C79ECF2D4445C CRC64;
     MTKDRPVNLA ALDAHWRAAN YLAAGQIYLM SNPLLTEPLR PEHIKPRLLG HWGTSPGLNL
     VHTHLNRVIK DRGLDAVCIW GPGHGGPAVL ANSWLDGSYA QTYPDVSRDA AGMARLFRQF
     SFPGGVPSHV APETPGSIHE GGELGYSLAH AYGAAFDNPG LLVACVIGDG EAETGPLAAS
     WHANKFLDPV HDGAVLPILH LNGYKIANPT VLSRIPEDEL DSLLTGYGYE PLHVTGSDPG
     KVHLAMARAM DHALERIAEG RQRSGRPRWP MIVLRTPKGW TGPAEVDGVP VEGTWRSHQV
     PLANVRENPD HLRQLEAWLR SYRPEELFDG EGRPTAQVLA CVPDGDLRLG ANPHANGGLL
     TRALPVPPLE HFAVPVDKPG ATQHEPTRVL GGLLAQVMAD TAGRRDFRVV GPDETESNRL
     GALFEVTGKA WQAETLDTDE NLSSDGRVME ILSEHVCQGW LEGYNLTGRH GLFSCYEAFV
     HIVDSMVNQH IKWLKTSRHL PWRAPIPSLN YLLTSHVWRQ DHNGFSHQDP GFVDHVLNKS
     PDVVRVYLPP DANTLLSVAD HVLCSRDYVN VIVAGKQPCF DWLSLDQARA HCARGAGIWE
     WAGTEDGTRE PDVVLACAGD VPTLEVLAAA ALLRRHLPDL AVRVVNVVDL AKLLPREEHP
     HGMGDLEYDA LFTRDKPVIF AYHGYPWLIH RLAYRRAGHA HLHVRGYKES GTTTTPFDMV
     VRNDLDRYRL VMDVIDRVPG LAARAAAVRQ TMADTRTRHH AWIREHGTDL PEIADWTWTG
//