ID A0A0M8SWJ0_9ACTN Unreviewed; 1039 AA.
AC A0A0M8SWJ0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:KOU46070.1};
GN ORFNames=ADK54_14635 {ECO:0000313|EMBL:KOU46070.1};
OS Streptomyces sp. WM6378.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415557 {ECO:0000313|EMBL:KOU46070.1, ECO:0000313|Proteomes:UP000037774};
RN [1] {ECO:0000313|Proteomes:UP000037774}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM6378 {ECO:0000313|Proteomes:UP000037774};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOU46070.1}.
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DR EMBL; LGDD01000144; KOU46070.1; -; Genomic_DNA.
DR RefSeq; WP_053726056.1; NZ_LGDD01000144.1.
DR AlphaFoldDB; A0A0M8SWJ0; -.
DR PATRIC; fig|1415557.3.peg.3269; -.
DR OrthoDB; 9772207at2; -.
DR Proteomes; UP000037774; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR Gene3D; 2.60.40.2220; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 518..597
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1039 AA; 113974 MW; 63F321D7E8F7EF09 CRC64;
MHDDRALVEG RLERAMRQFV RPAQYAARVP MALAVWHVPD EPVPVARALT AAYEPFEAGT
EWGRPWSTSW FRIEGRVPEA WAGRRVEAVI DPGFTGAGPG FQAEGLVYDT SGVPLKGIHP
RNRHIPVAAP AAGGEEVALL LEAAANPAVL HDFEPTPLGD VLTAGHGPIY RFAAADLAVL
DDEVWHLVLD VEVLSELMQE LPADRARRHG ILRALERMLD ALDLHDVAGT ATAARAELTD
ALSRPAGPSA HRVSAAGHAH IDSAWLWPLR ETVRKAARTF ANVTALAADY PELVFACSQA
QQYAWVRDHQ PHIWRSIKKA VENGNWAPVG SMWVESDANM PGGEALARQI VHGKRFFLEE
LGVETEEIWL PDSFGYTAAF PQLAKLAGVK WFLTQKLSWN QTNRMPHHTF WWEGIDGTRV
FTHFPPVDTY NSQFHGAELA HAERNFSEKG LATRSLVPFG WGDGGGGPTR EMLEKARRLR
DLEGSPRVTV EPPSAFFAAA HAEYGERAPV WSGELYLELH RATYTTQAKT KQGNRRSEHL
LREAELWTTA AALRSPDYSV PYDDLDRLWK TVLLHQFHDI LPGSSIAWVH REARETYERV
RAELEGIVAG AVSALGGARQ PTVLNASPYA RNAVVDAAAE DAPGGQPLPG GRALLAVHVP
PLAATALPRA AASAPPVTVA RGGSTLVLDN AVVRIVVDHE GLLTSVRDLV ADREVLAPGS
RGNLLQLHPD HPNQWDAWDI DRHYRRRHTD LTDADSVELV EEGPLRAAVR VVRSFRSSRI
TQEIRLSCAT PRVDVVTEVD WRESEKVLKA AFPLDVHAER STAEIQFGHV HRATHVNTGW
DAARFEICAH RWLRVAEPSY GVAVLNDSTY GHDVTRVPHD AGLGTTVRLT LLRAPHSPDP
ATDVDVHRFS YALLPGAEVT DAVAEGLALN LPLRVAPAAE VAPLVTVDDP AVTVEAVKLA
EDRGGDVVVR LYESAGSRVR AVLRPGFPCG RAEFTDLLER PLGEAPLSAE GIALELRPFQ
IVTLRLRGDR EQQEGSPRA
//
