ID   A0A0M8TCK2_9ACTN        Unreviewed;       308 AA.
AC   A0A0M8TCK2;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha {ECO:0000313|EMBL:KOU56479.1};
GN   ORFNames=ADK57_42065 {ECO:0000313|EMBL:KOU56479.1};
OS   Streptomyces sp. MMG1533.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1415546 {ECO:0000313|EMBL:KOU56479.1, ECO:0000313|Proteomes:UP000037741};
RN   [1] {ECO:0000313|Proteomes:UP000037741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MMG1533 {ECO:0000313|Proteomes:UP000037741};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOU56479.1}.
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DR   EMBL; LGDG01000272; KOU56479.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M8TCK2; -.
DR   STRING; 1415546.ADK57_42065; -.
DR   PATRIC; fig|1415546.3.peg.9068; -.
DR   OrthoDB; 9766715at2; -.
DR   Proteomes; UP000037741; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037741}.
FT   DOMAIN          1..297
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   308 AA;  32987 MW;  619DC68E38B5E36B CRC64;
     MVRIRLFETE AGKLMEAGKL PGFLHLYVGQ EAVAAGVMAA LRDDDQITST HRGHGHAVAK
     GVSFKHMYSE LYGRVTGACL GRGGSMHIND VSLGMLGANG IVGAGVPIAV GAAFAARYRG
     EDNIAVTFFG DGATNIGSFH EGANMAAILR LPVLFICENN GYAEFTPQSK HMLITDVADR
     AAAYGMPSVI VDGMDAVAVH QATVEAVARA RAGEGPMFIE AKTYRYYDHQ GVKGLRHPYR
     SDAEVEEWKA RDAIDLLEAR ALADGTATRA ELDDTWQRTR DEIAEAIAYA EASPLPDTAD
     LLLNVYSG
//