ID A0A0M8YP64_9ACTN Unreviewed; 843 AA.
AC A0A0M8YP64;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:KOX33424.1};
DE Flags: Fragment;
GN ORFNames=ADL06_09140 {ECO:0000313|EMBL:KOX33424.1};
OS Streptomyces sp. NRRL F-6491.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519495 {ECO:0000313|EMBL:KOX33424.1, ECO:0000313|Proteomes:UP000037743};
RN [1] {ECO:0000313|EMBL:KOX33424.1, ECO:0000313|Proteomes:UP000037743}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-6491 {ECO:0000313|EMBL:KOX33424.1,
RC ECO:0000313|Proteomes:UP000037743};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOX33424.1}.
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DR EMBL; LGEE01000077; KOX33424.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M8YP64; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000037743; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 68..143
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 160..585
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KOX33424.1"
FT NON_TER 843
FT /evidence="ECO:0000313|EMBL:KOX33424.1"
SQ SEQUENCE 843 AA; 88167 MW; D8C00F0B2C166B7F CRC64;
HHPHTTPLPT YAFQRRRYWI EDAARAIKSP APGLPREGKA GTAGLSADDP RGALLARLGP
LSPSARRRAV SDLVDEHIAA VLEYGPGERI DRHTAFQKLG FSSLMATELR AALVNATGLR
LPTGLLFDHP TPEALAGFVE GELLGAGGTD TEAAATAADD DPIAVISMAC RYPGGVASPE
DLWRLVSEGG DAVSAFPTNR GWAEDLYDPD SERQGKSSVR HGGFLHDAGE FDAAFFGISP
REALAMDPQQ RLLLQTAWEA VERARLLPES LRGTRTGVFV GATALEYGPR MQDAPASVQG
NVLTGSTTSV LSGRIAYQLG LLGPAVTADT ACSSSLVALH LAIRSLRSGE TNLALAGGVT
VMSSPGMFVE FSRQHGLAAD GRCKSFAAGA DGTGWSEGVG LLLLERLSDA RRNGHTVLAV
LRGSAINQDG ASNGLTAPSG VAQQSVIRQA LADAGLAASD VDAVEAHGTG TRLGDPIEAE
ALIATYGTGR EDRSPVYLGS LKSNIGHAQA AAGVGGVIKM IEAMRHGVLP RTLHVDEPTP
MVDWSAGAVE LLAREKEWPG AGRPRRAAVS SFGISGTNAH VVLEYDPEAE ASVSRPSGGP
ATATEEAVPE AGGLPAPWFL SGRDGRALRA QAARLLDHLA SGADPVAVGR SLAATRTVFE
ERAAVLGPTA EERLDALAAL AEGRDHPKVI AGSASNAGRT AFLFTGQGAQ RIDMGRELRS
VSTVFAAALD EVFEAFDPHL EHPLATVLFA EPDSPEAELI HQTAYTQPAL FAVEVALYRL
VESFGLRPDY VAGHSIGEIT AAHIAGVFNL NDAAHLVTTR ARLMQNATPG GTMIAIQATE
EEL
//
