ID A0A0M9ADA6_9HYME Unreviewed; 2101 AA.
AC A0A0M9ADA6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=U5 small nuclear ribonucleoprotein 200 kDa helicase {ECO:0000256|ARBA:ARBA00034541};
GN ORFNames=WN51_00841 {ECO:0000313|EMBL:KOX80923.1};
OS Melipona quadrifasciata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Melipona.
OX NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX80923.1, ECO:0000313|Proteomes:UP000053105};
RN [1] {ECO:0000313|EMBL:KOX80923.1, ECO:0000313|Proteomes:UP000053105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0111107301 {ECO:0000313|EMBL:KOX80923.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KOX80923.1};
RA Pan H., Kapheim K.;
RT "The genome of Melipona quadrifasciata.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ435694; KOX80923.1; -; Genomic_DNA.
DR STRING; 166423.A0A0M9ADA6; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000053105; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053105}.
FT DOMAIN 485..668
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 679..916
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1328..1473
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1506..1714
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 52..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..233
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2101 AA; 239079 MW; 9BB21577FC039437 CRC64;
MADAAARQLQ YEYKASINVR MLQADVRLIE RRSRDEATGE VMSLVGKLDG TRMGDRAQRT
KPGKAEERKV KRQKRDEAQY DFARMKGATL LSEGVDEMVG IVYRPKTQET RQTYEVLLSF
IQEALGDQPR DILCGAADEV LAVLKNDRLK EKEKKKETEL LLGPLAEERF ALLVNLGKKI
TDFGSDEKTT TSEENIDETY GINVQFEESS EEDDEDVYGE VRENDDEGDE GEEANDDRAI
HAENLGGAEE MKKEKPLHPL DIDAYWLQRR LSRIYDDAMV SQARAAEVLA VLKDAGDDRD
CENQLVLLLG YDCFDFIKQL KKYRHTIAYC TMLASSQSES ERQKIRNKMN DDPVLAKILR
QLDTGKGDDD ADETMEARAQ RKRREENEDT GGPGGQVQGT RNLIDLEDLI FAQGSHFMAN
KRCQLPDGSF RKQRKGYEEV HVPALKPKPF AENEKLYPID QLPKYVQPAF EGFKTLNRIQ
SRLFQAALES DENLLLCAPT GAGKTNVALL CMMREIGKHI NADGTINADE FKIIYVAPMR
SLVQEMVGTF GKRLSTYNLT VSELTGDHQL TREQIAATQI IVCTPEKWDI ITRKGGEKTF
TSLVRLIIID EIHLLHDERG PVLEALVART IRNIETTQED VRLIGLSATL PNYQDVAAFL
RIKPESGLFY FDNSFRPVAL EQQYIGVTEK KALKRFQVMN EIVYEKTMEH AGRNQVLVFV
HSRKETGKTA RAIRDMCLEK DTLGQFLREG SASMEVLRTE AEQVKNQELK DLLPYGFAIH
HAGMTRVDRT LVEDLFADRH IQVLVSTATL AWGVNLPAHT VIIKGTQVYN PEKGRWVELG
ALDVLQMLGR AGRPQYDTKG EGILITNHSE LQYYLSLLNQ QLPIESQLIS KMSDMLNAEI
VLGTIQNIRD AVTWVGYTYL YIRMLRCPNL YSISQDKLKE DPLLELHRAD LIHSAAVGLD
RSGLIKYDRK SGNFQATELG RIASHYYCTH ETMAIYNQLL KRTLSEIELF RVFSLSSEFK
HINVREEEKL ELQKLMERVP IPVKESIEEA SAKVNVLLQA YISQLKLEGF ALMSDMVFVT
QSASRLMRAI FEIVLFRGWA QLADKCLSLC KMIDRRMWQS MSPLRQFRKM PEEIVKKIEK
KNFPWERLYD LGPNEIGELI RVPKLGKTIH KYIHQFPKLE LSTHIQPITR STLRVELTIT
PDFQWDEKVH GASEAFWILV EDVDSEVILH HEYFLLKAKY ATDEHLIKFF VPVFEPLPPQ
YFLRVVSDRW IGAETQLPVS FRHLILPEKN LPPTELLDLQ PLPITALRNS KFENIYADKF
PQFNPIQTQV FNAIYNSDDN VFVGAPTELV YVDWSAKFNQ QLGRKVVLLT GETGTDLKLL
AKGQIIITTA DKWDVLSRRW KQRKNVQNIQ LFIVDELQLI GGEEGPVLEV ACSRARYISS
QLDKPTRIIA LSASLADAKD AAQWLGAPAA ATFNFHPSVR PVPLELHVQG INITHNASRL
AAMAKPVYNA ILRHASHKPV IVFVPTRRQA RLTAIDLLTF TAAEGQPSRF FHAEEADIKP
FLDRMTDKTL KETLSQGVAY LHEGLSVDDR HLVEQLFDSG AIQIAVATRD LCWGLSISSH
LVIVMDTQCY NGKTHAYEDY PITDVLQMVA RANRPLEDDD AKCVLLCQSS KKDFFKKFLN
EPLPVESHLD HRLHDHFNAE IVTKTIENKQ DAVDYLTWTF LYRRLTQNPN YYGLQGVTHR
HLSDHLSELV ESTLSDLEQA KCVAVEDEMD TLPLNLGMIA AYYYINYATI ELFSLSLNNK
TKIRGLLEII SAAAEYETVP VRQREENLLR SLATRLPHAP QAARMADPHV KAQLLLQAHL
SRIQLGPELQ KDTELVLSKA IRLIQACVDV LSSSGWLAPA VAAMELAQMV TQAMWSKDSY
LKQLPHFTVE TIKRCTDKGV ETVFDVMELE DDDRNRLLQL SETQMADVAK FCNRYPNIEM
SYEVQDKDKL RSGGTVNVIV QLEREDEVTG PVVAPFFPQK REEGWWVVIG DPKTNSLLSI
KRLTLQQKAK VKLDFVAPAP GQHSYTLYFM SDAYLGCDQE YKFTISVEEY ESDVSSGSES
D
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