ID A0A0M9ZEI5_9ACTN Unreviewed; 470 AA.
AC A0A0M9ZEI5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=GntR family transcriptional regulator {ECO:0000313|EMBL:KOV51626.1};
GN ORFNames=ADL00_40050 {ECO:0000313|EMBL:KOV51626.1};
OS Streptomyces sp. AS58.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1519489 {ECO:0000313|EMBL:KOV51626.1, ECO:0000313|Proteomes:UP000037758};
RN [1] {ECO:0000313|EMBL:KOV51626.1, ECO:0000313|Proteomes:UP000037758}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AS58 {ECO:0000313|EMBL:KOV51626.1,
RC ECO:0000313|Proteomes:UP000037758};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOV51626.1}.
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DR EMBL; LGDU01000394; KOV51626.1; -; Genomic_DNA.
DR RefSeq; WP_053763208.1; NZ_LGDU01000394.1.
DR AlphaFoldDB; A0A0M9ZEI5; -.
DR PATRIC; fig|1519489.3.peg.9009; -.
DR OrthoDB; 594134at2; -.
DR Proteomes; UP000037758; Unassembled WGS sequence.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000037758};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 24..92
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
FT REGION 99..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 470 AA; 50232 MW; 17A5E0D93419277F CRC64;
MADSWVNSAE RIGADLHLDL SGPGGRRAAL TRALREAVRG GRLAPGTRLP PYRSLAADLG
VARNTVADAY AELVAEGWLT ARQGAGTRVA ERAEPLRAPA RDTREAAVRA RGPRHDLRQG
TPDASAFPRT TWLASYRRAI QQAPHEVFGP GDPAGRPELR EALSEYLARA RGVRTEPGRI
VICSGFAHAL RLLFGGGVLR GPLAVEAYGL GFHRELLAAA GARTVPLPLD ADGARVGRLA
RERAVLLTPA HQFPTGGPLH PARRAAAVDW ARGRGGVVLE DDYDGEFRYD RKPVGALQGL
DPERVIHIGS VSKSMSPALR LGWMALPERY VDGVLAAKGE REAWASVLDQ LALADFIAEG
AYDRHVRRMR QRYRSRRDRL VAALAEQAPH VEVTGVAAGL HAVLRLPPGT ERATVRAAGS
RGLALDGLAA FRHPTTDMPA PDGLVVGYAT PSDHAYGAAL DALCGVLPPP
//
