ID A0A0N0BGR1_9HYME Unreviewed; 381 AA.
AC A0A0N0BGR1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000256|ARBA:ARBA00019998};
GN ORFNames=WN51_13475 {ECO:0000313|EMBL:KOX74914.1};
OS Melipona quadrifasciata.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Melipona.
OX NCBI_TaxID=166423 {ECO:0000313|EMBL:KOX74914.1, ECO:0000313|Proteomes:UP000053105};
RN [1] {ECO:0000313|EMBL:KOX74914.1, ECO:0000313|Proteomes:UP000053105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0111107301 {ECO:0000313|EMBL:KOX74914.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KOX74914.1};
RA Pan H., Kapheim K.;
RT "The genome of Melipona quadrifasciata.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ECSIT family.
CC {ECO:0000256|ARBA:ARBA00007674}.
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DR EMBL; KQ435776; KOX74914.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N0BGR1; -.
DR STRING; 166423.A0A0N0BGR1; -.
DR OrthoDB; 4098911at2759; -.
DR Proteomes; UP000053105; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR029342; ECIST_C.
DR InterPro; IPR010418; ECSIT.
DR InterPro; IPR046448; ECSIT_N.
DR PANTHER; PTHR13113; ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS; 1.
DR PANTHER; PTHR13113:SF1; EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL; 1.
DR Pfam; PF14784; ECSIT_C; 1.
DR Pfam; PF06239; ECSIT_N; 1.
DR SMART; SM01284; ECSIT_Cterm; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053105};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 235..353
FT /note="ECSIT C-terminal"
FT /evidence="ECO:0000259|SMART:SM01284"
SQ SEQUENCE 381 AA; 44513 MW; C58FB2A49887CFA6 CRC64;
MRKIVISLNK LPVIKKHASI QLTIVNKFHN NDILHTKNEP NVDVTPHHFN VQVKVKETFL
EIIRIYKRND SNRKAQLEFI QTALKYMNEF GVHQDIEAYK ALLDIFPRGR YVPENRFQVM
VYHYPKHQDT ALRILNKMEE NFVIPDYDVQ KMILEIFGKN NLVMKKCFSM FYWQPKFSQL
NPWPIPRPTP TDAKVLAEYG LKKISSADLQ ANVTLYRTKD VPDAIDDTWI FSSMSKSQQE
LLAVQPTDKS LRVEGPFSIW VADYYLNYFV LKGDPIKREV IYGEYDDVSN MKIPFWERHN
FKIPVTIHEQ DDGVYYAICA SGTSSKDSLL SWIRCLQKTN PILEKIPIVF KLRSLTNEQL
CIENDARKQI SRDADADTTG K
//
