ID A0A0N0MUR9_9ACTN Unreviewed; 316 AA.
AC A0A0N0MUR9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:KPI07579.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:KPI07579.1};
DE Flags: Precursor;
GN ORFNames=OK074_0289 {ECO:0000313|EMBL:KPI07579.1};
OS Actinobacteria bacterium OK074.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1592327 {ECO:0000313|EMBL:KPI07579.1, ECO:0000313|Proteomes:UP000037991};
RN [1] {ECO:0000313|EMBL:KPI07579.1, ECO:0000313|Proteomes:UP000037991}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OK074 {ECO:0000313|EMBL:KPI07579.1,
RC ECO:0000313|Proteomes:UP000037991};
RA Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT "Draft genome sequences for four actinobacteria strains OK006 OK074 OV450
RT and OV320.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI07579.1}.
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DR EMBL; LJCV01000252; KPI07579.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N0MUR9; -.
DR PATRIC; fig|1592327.3.peg.5224; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000037991; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:KPI07579.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037991}.
FT DOMAIN 10..166
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 170..295
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT REGION 294..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 176
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 316 AA; 32119 MW; 7C5FA4C541016AD9 CRC64;
MSPAPRPRTA VIGLGAMGLP MARRLAAQLP VSVYDIAPER RALIATAGGT DAVSPAEAAR
DADVVLLAVR DQAQVDGALF GELGAAETLR PDTAVVLTST VGPDAARATA ERLAERGILT
VDAPVSGGPV RAGDGDLLIV VGAEDKALDL ARPVLDLLAS TLTIVGPRPG DGQALKAINQ
LLAGVHIAAA AEAIALARGL GLDPATVVES LRHGAAGSFM FGDRGPRMVE TYESDTAPEV
KSRLDIFVKD MGIVTGIAKD AHVPVPLASA AQQLYLLGEA AGLAARDDSS VVTVLSPKPA
EPAKAVNSPA RNGADR
//
