ID   A0A0N0TNX0_9ACTN        Unreviewed;       739 AA.
AC   A0A0N0TNX0;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Membrane protein {ECO:0000313|EMBL:KOX16596.1};
GN   ORFNames=ADL06_33485 {ECO:0000313|EMBL:KOX16596.1};
OS   Streptomyces sp. NRRL F-6491.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1519495 {ECO:0000313|EMBL:KOX16596.1, ECO:0000313|Proteomes:UP000037743};
RN   [1] {ECO:0000313|EMBL:KOX16596.1, ECO:0000313|Proteomes:UP000037743}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL F-6491 {ECO:0000313|EMBL:KOX16596.1,
RC   ECO:0000313|Proteomes:UP000037743};
RA   Noorani M.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOX16596.1}.
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DR   EMBL; LGEE01000277; KOX16596.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N0TNX0; -.
DR   PATRIC; fig|1519495.3.peg.7147; -.
DR   OrthoDB; 7051771at2; -.
DR   Proteomes; UP000037743; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        186..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        231..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        281..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        311..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        540..559
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        566..588
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        608..631
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        652..673
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        685..708
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          81..346
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          413..720
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   739 AA;  78537 MW;  3C24EFCEE9731CFC CRC64;
     MSQLPVRIAR WSARHAWRAI AGWFVFVVLC LGAGIAVGSN EATVEDFRVG EAGRAEAMAA
     EGGLQRRPTE QIIFYAKSGP PDMAAADSAA RDLTERMRKL PEVESVAAPV RSTDGKVLRV
     SVVLKGPELD GRKNVVPLLE QTAKVRDDHP DLVVEETGSP SISKGVNDQR GEDLALSERI
     TLPVTLVTLL IVFGSVVMAS VPLLLALSSI AGALGLSMIA SHGLPDPGVG TNMILLIGLA
     VGVDYTLFYL KREREERARA GGRLGSEALV ELAAATAGRS IVVSGLAVIA STATLYLAGD
     VIFSSLATGT ILVVAVAMVS SLTVLPALLV TIGRRSERRS ARRAARRASR GKPVRTKRAA
     AETGRLFGAL LRPAQKRPAV TLGVSVLVML ALAAPALGMK LIDPGKDTFS RKIPAMQVYD
     RLNAAFPELL VKHEVVARST PDRAAEVRRA LADLGRRAQA DPLFARTAEP EVRTSADGRI
     SVLELAVPYP APSDEATESL GHLRKDHVPA TVGMLSGVET GVSGDVARGH DYVHHERSKL
     PLVIGFLLLV TFGMTVWAFR SVVIGLIGVV LNLLSAGASL GLLVVFFQGT WAEGLLAFDS
     LGAIASRVPL FLFVILFGLS MDYQVFVVSR IQEAVHDGMS AREAVLDGIT RSAKVVTSAA
     IVMVTVFGAF VALHLTEMKQ MGFCLAVAVL LDAVVIRLMV LPSLLLLLGE RAWWPLRPTR
     SSLTGPSTTP AARPCEKVV
//