ID   A0A0N1ADN6_9PROT        Unreviewed;      1997 AA.
AC   A0A0N1ADN6;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Alpha-2-macroglobulin {ECO:0008006|Google:ProtNLM};
GN   ORFNames=IP80_10575 {ECO:0000313|EMBL:KPF48483.1};
OS   beta proteobacterium AAP65.
OC   Bacteria; Pseudomonadota; Betaproteobacteria.
OX   NCBI_TaxID=1523424 {ECO:0000313|EMBL:KPF48483.1, ECO:0000313|Proteomes:UP000037849};
RN   [1] {ECO:0000313|EMBL:KPF48483.1, ECO:0000313|Proteomes:UP000037849}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AAP65 {ECO:0000313|EMBL:KPF48483.1,
RC   ECO:0000313|Proteomes:UP000037849};
RA   Zeng Y., Feng F., Liu Y., Koblizek M.;
RT   "Novel Diversity of Limnic Aerobic Anoxygenic Phototrophic Bacteria as
RT   Revealed by High-throughput Strain Identification and Genome Sequencing.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPF48483.1}.
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DR   EMBL; LJHW01000018; KPF48483.1; -; Genomic_DNA.
DR   STRING; 1523424.IP80_10575; -.
DR   PATRIC; fig|1523424.3.peg.721; -.
DR   Proteomes; UP000037849; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd02891; A2M_like; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   Gene3D; 2.60.40.3710; -; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR   InterPro; IPR041203; Bact_A2M_MG5.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF11974; bMG3; 1.
DR   Pfam; PF17972; bMG5; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000037849}.
FT   DOMAIN          1109..1248
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          1313..1404
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   REGION          582..616
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1997 AA;  214962 MW;  532F72686DD73490 CRC64;
     MAAFFAALLG TWSAPPWLRW LGATLHGGSS QLTGRVRAQP RASASLLIGV LAVAAAAYAG
     YRWWQTRPQP VQVDFSVTNP PLTDFANQGL PQPLVLQFEQ SVAPLEGVGK AMATATASAA
     AASAPGSAPP AAPGVQPALP TLSPALAGTW RWASDRQLEF QPQADWPVGQ RFQVTLPRAF
     IAPQITLARQ AFEFDSAGFV PKLNAASFHQ DPLNPALKKA IFEIGFTHPV NAAEFERRVE
     LRLAGQSEGV LGVGRETTRF KVSYDKLYLN AYVHSVPLPI PKEATALQLT LAAGASAQAG
     GTPSAAVLKG SVQVPGLYSL NVAAQGISIV TNEQYEPEQV LTLQTSQLVH EREMAQALSA
     WVLPLQNPAV RKEEQGEEPY AWADPAEITE QVLKLATKLP LAPVPAEQEH TQNHAFKLRA
     EVGRTVYLRV DGKLKSFGGY LMRENAQALV AVPPYPAELR ILSQGALLPM SGDKKVAVLV
     RDLPGLRVEL ARVQPSQLQH LVSQSQGSFS NPEFLGSFGP DNLSDRFEKR IPLPGLARGK
     PHYEALDLAA YLAPAGEPRR GLFLLQVQGY DPVAEARAER ERLAALDPNR PVQAEAETNE
     GEAGYDESGS EVTDPTQLQE RRLLLVTDLG MLVKQSIDGT RDVYVQSLYS GEPVAGVTVD
     VVAKNGSTLF TQTTDASGRA RFEKLDGLQR ERAPLLLLAR KGGDMSFMPL NRGDRQLDFS
     RFDVGGALNA RSAEQLSAYL FSDRGIYRPG ETMQIGMIVK NADWARPLAG VPLEAEVLDA
     RGLAVKRERV RVGAGGFFEI SHTTQDSSPT GTYAVNLHVM KDGQALRQIG STSVKVQEFQ
     PDRMKVSARL LGVGEAPVPA VGEGWVHPRE LQARIEAMNL FGTAAEGRRV AVSLTLSPAY
     PSFRQHAGYQ FYDPQRAKEG FNETLPDGRT DAQGRASFDL QLSRYARATY RLGLLAQVFE
     PEGGRSVAAE AGVLVSELPF LVGVKHDGDL GYVSRGSTRI SRLLAIAPNG KPLAAEGLTL
     QRVERKMVSV LMRQANETYR YESRRKDTLV EEKRVALPAA GLALALDTRT PGNYSYVLRD
     AAGLELNRID YSVAGQGNVS RSLERNAELQ ITLNKKDYQP GEEIELSIRA PYVGAGLITI
     ERDKVYAQTW FKSSTTASVQ KIRVPKDFEG NGYVNVQFLR DPTSDEIFMS PLSYGVVPFA
     TSLAPRTLAL QLQAPALSKP GQVMKFRLAS NKPARAVVFA VDEGILQVAR YQTADPLGHF
     FQKRALEVRS AQILDLLLPE FKRLMAAAAP GGDEAGGNAR FLNPFKRRGE APAVYWSGIV
     DLQGEREFSY TVPEHFNGAM RVMAVAVNDG AVGVAQTQAL VRGDFVLSPN LPLAVAPGDV
     FEVSVGVANN VASSGADAPV QLTLKAAPTF EVQGAATQTL KIGAGREGVA RYRLKVKDAA
     SATLGSATLQ FTSNLGSNAA ISSTRRMDVS VRPATPRATT LALGHFKGRT EVPTPRDLVP
     EFRRQELAVS VLPLAVAPGL MRYLDEFEHA CTEQLVSQAL PALVLARRSE FSAERTPAAA
     ARTLESTLRT LRTRQNAQGG FGLWGASVQA DEFVSVYALH LMLEARELEV PGATVPADLL
     QQGLRYLQQL AASPPANLAA ARHRAYALYL LTRQGAISTP QLASLRQVLD EQHAATWKQD
     PAAAFMAATY QLLKQERAAA ELITPLVQRF EAGPAKQAYA DYTDPGITGG QLLYLLARHF
     PARLKTLAPD ALQRHIVPLG GGGMNTLSAA WTVLAFEGMA RQLGPQAEGQ LSAAQINAQG
     QATPLKLPAN LLPRVAFEGG TVKLQLANAG DAVGWYAVTQ SGFDRVPPTA VLKSGLEVLR
     EYVGADGKPA TTVKVGDELT VRLSLRALAL DGQGGGAAQV GEVALTDLLP GGFEPVQQRN
     ETGGSSTVSG PALAHAEVRE DRIVVYASAS NQVQTYTYRI RATNAGEFTV PPAYAQGLYE
     TQRQARSLAG KVTVAAP
//