ID A0A0N1GBL0_9ACTN Unreviewed; 4656 AA.
AC A0A0N1GBL0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=FkbH like protein {ECO:0000313|EMBL:KPI19413.1};
DE EC=2.3.1.179 {ECO:0000313|EMBL:KPI19413.1};
DE EC=2.3.1.94 {ECO:0000313|EMBL:KPI19413.1};
GN ORFNames=OK006_9711 {ECO:0000313|EMBL:KPI19413.1};
OS Actinobacteria bacterium OK006.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1592326 {ECO:0000313|EMBL:KPI19413.1, ECO:0000313|Proteomes:UP000037912};
RN [1] {ECO:0000313|EMBL:KPI19413.1, ECO:0000313|Proteomes:UP000037912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OK006 {ECO:0000313|EMBL:KPI19413.1,
RC ECO:0000313|Proteomes:UP000037912};
RA Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT "Draft genome sequences for four Actinobacteria strains OK006 OK074 OV450
RT and OV320.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI19413.1}.
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DR EMBL; LJCU01000030; KPI19413.1; -; Genomic_DNA.
DR PATRIC; fig|1592326.3.peg.1250; -.
DR Proteomes; UP000037912; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0046483; P:heterocycle metabolic process; IEA:UniProt.
DR GO; GO:1901360; P:organic cyclic compound metabolic process; IEA:UniProt.
DR CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010037; FkbH_domain.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR010033; HAD_SF_ppase_IIIC.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01686; FkbH; 1.
DR NCBIfam; TIGR01681; HAD-SF-IIIC; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS51186; GNAT; 1.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:KPI19413.1};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KPI19413.1}.
FT DOMAIN 24..98
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 115..539
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1809..1884
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1906..2332
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3569..3646
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4501..4654
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
FT REGION 626..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3649..3675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4102..4128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3651..3675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4656 AA; 492325 MW; 139DCB895803889D CRC64;
MPASESPKQF PEMSLTTSED VTSEDVRAWL TSAVAEAAGL DPLAVDPERP IAEFGLGSRQ
LVTLAAELSG RIGRPVEPSL VFDHPTVAAL AAAVLDDGPV GAAAPVPADA PVRGDEDIAV
ISMGCRYPGG ADDPEALWRL LATGEDAITE VPAGRWDTRG LYDPDPEAPG KAYTLRGGFL
SDIDRFDAHF FGISPREAAA MDPQQRLLLR TAWETIERAG IVPDTLNGSS TGVYIGLYDS
GYQASAALGR LDGHVGTGSA SSVASGRIAY TLGLQGPAVT VDTACSSSLV ALHLAARALA
SGECDLALAG GATLLVTPRG HVEFSRLRGL SPSGRCSPFS TDADGVVWAE GCGLVLLKRL
ADARRDGDRV LAVVKGSAIN QDGRSQGLSA PSGPAQERVV RAALDAAGLR PDDLDHVEAH
GTGTRLGDPI EGRALAAVFG PGRPADRPLG VGSLKSQIGH TQAAAGIGGV IKTVLALGHE
LLPASLHADT PTEHVDWAGG GLRVHSVARA WPRGGDRVRR AGVSAFGISG TNAHVVLEEA
PRDLVRPATG TPLADLPGAT LFPLSARTLP ALRGQAARLL EALDAQPRPT LPEVAATLAH
HRTHFEHRAV VRATDRDGLL TALRALAEGP TDTDSDTDTD TDTGTGTVVG PQQTVPTGKV
AFVFPGQGSQ WTGMARDLLD RDPVFADELD RCDAALRPFT TWSVAAVLRG AEGAPPLDRV
DVVQPVLFAV MVSLAAVWRA RGVRPDAVVG HSQGEVAAAC VAGALSLNDA AAVVALRSQA
LTGLSGTGTM AVVALPHAEV ENRLADLDGR VCVAAVNSGR STVIAGDVEP LETLLADLDR
EQVFARRLDV DYASHSPGVE PVRATVLDEL DGVTTCPTSV AWYSTVTGEP VTEELEADYW
YTNLREPVRF APTVERMAAD GYRCFVELGP HPSLVTALHT VAEDSGHENL VAVGSLRRDE
DGPACLDRAT AELHVHGRRI DWRRLVPDTA PADLPTYAWD PRRHWIEPES TTGASGLFDR
AAHPLLGIQL QSPDETRWTF RGEWSEDTAD WLPDHTVFGR TVVSGTTLME LCRAALAVAR
PDDPADLTDL LLLSPLTLPD SGTVEVSVEV VTAGPVPEIT VHSRPRAQEA TGWTLHATVS
ASAPAAPTAD RPPVWPEAAE PAWTPETYER LTALGLGYGP AFQGVRSAVT TGDGELLARL
SLPPTARDAA DPYPLHPALL DAALHVAAGL DASDGRVLLP VAVGRCVLPP GGARELTAAV
RRTGGSGTDL TLDVTLWDTD GFPAGRLEGV RLRAADPADL NGASENARHL YEVVWTAVPE
QPDEAPGTEW AVVGDPSDPE VAGALRGLAA AGTHVRSGTG GADVNGAGGV DVRGTGGVDV
FVRFWPRPAT DAEPSAAAQE LAAAALAELR ALIALPQDEA PARTVWVTRG AVGAVDKDTV
PGLAQSVLWG LARSARAEHP ELGLTLLDLD DSDPADALLT AATHAEEPEL ASRAGTLLAP
RLVRARDRDA TGTPVGPDLV GRPALAPTDG TVLITGGLGA VGRHIARLLA EHGVPRLLLT
SRQGPDDPRA AEVAAELTGL GAEVEVAACD IADATAVAGL LGRIGEESPL RGVVHCAGVL
ADGVVAELTP ERLAQVLRPK VDGAAHLHRL TVDARLDLFL LVSSAAGVVG NAGQGNYAAA
NVYLDQLAHH RRALGLPGVS LSFGAWAGEG LAAAHADLDR MARLGHRALT SDQGRELVEL
ALRQGAPHLV AWALDLPRLR ETATTAATTG VGGTAAVWRS LLPAPRTGRS GGDGLADRLA
RLPEAERAER VLALVREEIS RALGLRSTES VRPDQPLREL GMDSVTAVEL RNRIGARIGA
KLPATLLFDH PTAARLAAHL LSTALAAGDR TTPATRPTRA TTPAADEPVA LVAMACRLPG
GVSDPEGLWN LVAEGRDAVG PFPAERWDVA ALHDPDPDAV GKSYAHEGGF LNDDDLTSFD
AGFFGITPKE AAAMDPQQRL LMETAWEALE RAGIVPAELA GSTTGVYVGM FGSDYLAGSR
LDQLDGYVGT GSALSVASGR LAYTLGLGGP ALTVDTACSS SLVALHLAAQ ALRAGECDLA
LAGGVTVMVT PGTFVEFSRL RGLSPTGRCR SFSDDADGAI WAEGAGMVVL KRLSDARRDG
DEVLAVLRGT AVNQDGRSQG LSAPNGPAQE QVIRRALELS GLRPADIDYV EAHGTGTTLG
DPIEANALAE VFGDSRPQDH PLYLGSLKSN IGHAQAASGV LGLVKVVQSL RHRTLPRTLH
ADTPSRHVDW ENSGLRLVRD TAPWPSSPGR TRRAGVSAFG ISGTNAHVIV EEAPPVEKAD
VKDEVPPGKR LFVLSGRSGA ALRGQAARLA DHLTEEAGED IALLDVAHTL ARHRSHFERR
AALVAGDRDE LLLRLDALAG GRPPPAAPRD DGTGKVAFVF AGHGGQWPGM GVELMAGSEA
FREELVRIDE AVRRRVGWSV LNALRAPEEF APLGRTEFLQ PVLFAVNASL AAAWRALGVR
PDAVVGHSLG EIAAAYSVGA LTLDEAVTVV TGRGQAVVPL VGKGGMLSLE LPPARVEELL
APFTGRLFVA AVNSARSTAV SGEADALAEL RDRLDERGIA ARPLTTPFAS HTPLMDQLRA
ELLDRFSDVR GVRTPTPLYS AVLAEPVPGD RLDADHWYAN LREPVRFADT IRRMLDDGYR
YFVELSPHPS LTSSIEAVAA EAGIDAVGIG SLRRQSDGHD VLLRGLGELY TAGHTPDWPL
LFPQGRRVDL PTYAFARERH WLAPAPASAG GSPLLGTHLE ASDEPDRHLF QADIDLDDSR
FAYLTDHRVT GEVWLPGAAF LDMALEAAST LRGGGEVQLA GVRFVQPLPL EVNRPVRLQL
VLSPAEDGFR DFTIASTPSG GHGAPWQRHV SGRLAVTAQT APDDEERLDA VRERCDEQVD
PAAVYAGLAA LGIDYGPAFR GLEEGRRTNV AALGRLARTP AAGHLLHPAV LDAAFHTAAL
PGGAPEGRAF VPAAVGRLTF TGLRTAPVWA TCRLRSVDGD TATVDLRLWD EDEQLILEAR
EFELAALSPL DGALFETRWQ PCPAAQQPPA EGSWLILADD TGVAAELAER LGSTVPRVIA
RRGESFGVEG PGRYLLDPAD PRHLARLLDE AFPDGPPERV VQLSALDAPA ITDAGTAEEA
ARLCCLSTLH LVRALADRPG RAPRLFVPAR GSQAAGDSTR VTHPQQALAW GFGLAVAQEY
PELSATLIDL PPTDGVDALW TQLRHADDER LVALRESGRL VPRLARTRPD DGGNGEVTSD
GVYLITGGLG GLGRVVAERL VRRGARRLAL MSRGEPDGHT ASWISGLEEH GTTVHLARAD
VADREELTAA LDAVRREAGP IAGVVHAAGV LDDATVANLT DERVLRVLAP KVLGTTLLTE
LIPEAESLVL FASAAGLLGS AGQSPYAAAN AFLDAWAHHL SRVDRRALSL DWGAWAGVGM
VAESGIRAAE TGRSGLLALS PQDGGELFER VLATSRRQLA PLALDWETLA HDPDAARTRP
ILGDLITVPT GGDGADDLVA SVFAATTARD RADRLEAYVR ARVGQVSEGT VDVSATTALK
ELGLDSLMLV RLRNAFAREL GAELPAATVF SASDIRGLAR ALGEVLPERD TAAQAGERRP
EARRPEAAVE VPESELRPAT RDVLRLLRSA RPGMPDAAHG VGLALRLTTP TTREALTDIL
TRLAGRHAAL RTAIVTGAGG EHARLLRVDR ELARPVLRWT DVPGDDELDG ADRLRRLLEP
PFDLANPPLW RFELLDSGAR GQVLAFGAHH AVSDLQSLLL VAGELDAELS GTSLGDAVTN
RDIDLLIEAQ QTDDTPGEGV TAWREAFQGS DRLDLTLARP RPATRSYRAG SVSVTIPDGL
MERVSAAASG LAITPAAFCL GTLTVLLARM RQKERFVLAV PVDTRIHADA YDAVGFFGVP
VPFPAEAGAG ERIEQVLRRT DGRLDRVLAK GAMFSDVLST LARQGLHRAN APLVEVYFNY
VRSAADRLAH LEVLPAGTGY SDLDLMITMT PDAGRIRLDH NLDILDAATS VELGEEFLRL
LAEAADDPTA AVRSMPDTAV EATPAVRSTS GMAVEVPEGA PEDTRHSPRR SLALAATFAL
GNLPLLCEAA VGEGARDGGL TVAEAPYHQV LAALRDPSGV FADPTAAVGV ALLRAADLER
FGPVDDALLA ELRTAFPAAL RAVSERTRKP LIVGFLPSAH ARDRFARWER EIADELAEVP
GIAVLRPDDW TRRHAVEEPF DERTERIAHL PFTPHFQAAV ALCLADVVRA VRRPAPKVIA
VDGDETLWGG VAGEIGPEAV DLTGPRALLA RRLLQWRAAG ALLALVSNND EATVRAVLDR
PDSLLKAEHF SVLSATWGPK SARLAEAART LGLGLDSFLF LDDNPVEIAG VRSALPEVLS
VTCPPSAELG EFLGRLWPLV PAAATAEDAL RARFYEQERD RDAVRAQAGF EEFLAQLELE
VDIRALSGAD VERAEQLVRR TNQFTLRGRS ADGGDLGRWR ECGEVWTAAA RDRFGDYGQI
GLLALRADGD QLDVLAWLMS CRALGRGVEE RLLRWLADRA DELGCVKVRL TAERTARNVP
ARRLLAALGD GDQDDERLET VVTPEHLRAF RSWRRG
//
