ID A0A0N1GLP6_9ACTN Unreviewed; 580 AA.
AC A0A0N1GLP6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Cobalamin B12-binding domain protein {ECO:0000313|EMBL:KPI23520.1};
GN ORFNames=OV320_0467 {ECO:0000313|EMBL:KPI23520.1};
OS Actinobacteria bacterium OV320.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1592329 {ECO:0000313|EMBL:KPI23520.1, ECO:0000313|Proteomes:UP000037870};
RN [1] {ECO:0000313|EMBL:KPI23520.1, ECO:0000313|Proteomes:UP000037870}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OV320 {ECO:0000313|EMBL:KPI23520.1,
RC ECO:0000313|Proteomes:UP000037870};
RA Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT "Draft genome sequences for four actinobacteria strains OK006 OK074 OV450
RT and OV320.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI23520.1}.
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DR EMBL; LJCX01000032; KPI23520.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N1GLP6; -.
DR PATRIC; fig|1592329.3.peg.1976; -.
DR Proteomes; UP000037870; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF12; BLL1977 PROTEIN; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDF00418; pactamycin_C-methyltransferase; 1.
DR SFLD; SFLDF00438; pactamycin_methyltransferase; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000037870}.
FT DOMAIN 33..168
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 210..451
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 580 AA; 64713 MW; 4DBD05F6AF684CDF CRC64;
MSDVVLLTPR EIATGALSLN NQNVTVTDEE YVQLDPALRI FYEKVRENLG LACITGYLRN
AGHSVTSLNL HGRTPSDDAI IELIRRERPR FIGISIMYDL HIIDAIRLIR CARIADPDVF
IAIGGAFCTY NAKLIAEQVP EADCVTFGEG ELTVVGIMDR LTAGTDWRET PGLFYRDGDR
VRSSGMPVLP DLGNLVWPAR DVLQYHKAAG IATPVASTFT SRGCHAKCTF CYAPRQPGVV
DGFWRMRPPG DVVDEIEYLQ REFGTRFIWF NDDNFGGAFG DGFAHAVEFA ETVLSRGLKF
QFHCEFRVDS GLIDHEALDL LHRAGLSSAL LGIESGSPGM LRRFKKGTTV AYNLDAARMF
KRKGLGLDPG WIMIEPKTTI DELWENLEFI VAARIHEADN PFFLINRAIA LRGTEMYDKI
EEPLPLADIE GMEGDAYEIL RTARRDYRVP DPRVEALWSA WSEVGEEISD RKENVLPFIA
QKIALGARRL RGTEHNPRAF LSRLRAWRNG LPELFLAFMN YGLVLAETGP PDLATRLTAD
LRDLVADYDA EHLGESFQEF GERVERVCGA AALVAAGAGR
//
