ID A0A0N1HTE8_LEPSE Unreviewed; 1376 AA.
AC A0A0N1HTE8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Putative myosin IB heavy chain {ECO:0000313|EMBL:KPI83118.1};
GN ORFNames=ABL78_7859 {ECO:0000313|EMBL:KPI83118.1};
OS Leptomonas seymouri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI83118.1, ECO:0000313|Proteomes:UP000038009};
RN [1] {ECO:0000313|EMBL:KPI83118.1, ECO:0000313|Proteomes:UP000038009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI83118.1,
RC ECO:0000313|Proteomes:UP000038009};
RX PubMed=26317207;
RA Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA Yurchenko V.;
RT "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT donovani.";
RL PLoS Pathog. 11:E1005127-E1005127(2015).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI83118.1}.
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DR EMBL; LJSK01000435; KPI83118.1; -; Genomic_DNA.
DR EnsemblProtists; KPI83118; KPI83118; ABL78_7859.
DR VEuPathDB; TriTrypDB:Lsey_0435_0030; -.
DR OMA; AHMQFYR; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000038009; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00065; FYVE_like_SF; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13140:SF729; HEAVY CHAIN, UNCONVENTIONAL MYOSIN; 1.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 11..790
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 886..925
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 1053..1115
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 237..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..683
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1235..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1254..1268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1292..1376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 122..129
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1376 AA; 152587 MW; AECACC3CC4D42C77 CRC64;
MTSEYKLRET VGVEDLVLLP QITEKAITDD LAVRYRSDLI YTNIGSVLLV VNPFKQIPGL
YNEAHMQFYR HSGRLGGAQD ALLEAQEPGD AAIGGPHIFA LAEDTYRRMV SEEENQCVII
SGESGAGKTE ASKQIMQYIS AVSGNTSDMQ KVKRIILESN PLLEAFGNAK TLRNDNSSRF
GKFLEVYFDI RGGPVGGHLS HFLLEKSRVS SQQEGECNFH ILYQLCVGAA MALEESATAS
HKTHPGKGTK DYVEEGESDL EDDSPIAWAE LFTEMHMQGL SDTAGYTRLG PASNVYPWKY
LRPTIASGRH ADNFTPRTGI DDAQGWKETL LAMEAMGMTK GDQISVIKVL CLVLHFGELE
FVAPAEGGEL AAGQQPCTLA NPEVLDLIAQ HLGVDAKALF KALTWRKLQV GATEVVFSPL
DAQQCRNTRD AIARALYEGV FEFIVSSVNI AFGDAPHALM LGVLDIYGFE IFAKNGFEQF
CINYVNEKLQ QIFIELTLRV EQEEYVRENI PWEAIKYFDN QIVCDLIESN RPPGMFAIID
DVCITMAKEE ESVADRKLLD KLDMNYHSHP NFVRSERGFI IKHYAGDVEY STDGFIGRNK
DRLGADVVEA LTQCKNSFVL EILTEVLADG MAAGSPTGAS AGAGATMRRT TTAGFKIRQQ
AADLMRTLKQ CTPHYVRTIK SNDMKRGNFF DEARVLHQVK YLGLLENVRV RRAGYSYRQY
FDKFLKRFKY TCPSTYPRPF RGTDKAACET ILSYLQNDHA VLPPQSYAIG TNKVFIRQPE
HVLALEQSRE AAFHSLSVTI QRAWRRYTQR KQLLRLKAKL DRSYQRRGKV RRADSVFRAY
EGLYVDLDSV VAAAGLQTAL GAAGGTLPRA LSSRLAVAAD AMFHFDPIAR AWHAFWSSSV
EAGQPRRKFF VNALTQETVW ERPREVDPPR LVFSCVAERL VNWATAKTVR EFIFVTSHDV
LYVVRERPRM EDVPADGTES SKKKRKEAKA KAVANQGAGG EVALEPCFTL QKRLDLRLLT
QVAVTAMADT VLVLRMLPVL APYRPVLDTV KTKTGPVQCE TCGRKATPAM RRANCPSCGR
LCCVRHCLIH ARPLPTMNGH TKPVHVCPAC VVGEPLEAVS DMVLLTPFKT ELAGTLCTHY
QERMGNPLPL LVSSSIPFSV WTPAPPLVGK RKAPSSAGKA KGRKGAAVAT AGEAEELPGV
LGGSYEVTLT CVASDDALTA DTVLVPAISC AALEAQPEAD KRSSRKSAVV VKPTKKRTKQ
DEDDLSAVPA DTPKVLTVVS PHGITASQIQ RMEAAREERR KAAAARRRQE EEEERKRESQ
REAERAAEHR RLVQERKKAK AAETARMEAE RAAHAKAAAD RREEAARLVA ERARRR
//
