ID A0A0N1IHL1_LEPSE Unreviewed; 714 AA.
AC A0A0N1IHL1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Putative pteridine transporter ft5 {ECO:0000313|EMBL:KPI83895.1};
GN ORFNames=ABL78_7055 {ECO:0000313|EMBL:KPI83895.1};
OS Leptomonas seymouri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI83895.1, ECO:0000313|Proteomes:UP000038009};
RN [1] {ECO:0000313|EMBL:KPI83895.1, ECO:0000313|Proteomes:UP000038009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI83895.1,
RC ECO:0000313|Proteomes:UP000038009};
RX PubMed=26317207;
RA Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA Yurchenko V.;
RT "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT donovani.";
RL PLoS Pathog. 11:E1005127-E1005127(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Folate-
CC biopterin transporter (TC 2.A.71) family.
CC {ECO:0000256|ARBA:ARBA00007015}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI83895.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LJSK01000312; KPI83895.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N1IHL1; -.
DR EnsemblProtists; KPI83895; KPI83895; ABL78_7055.
DR VEuPathDB; TriTrypDB:Lsey_0312_0010; -.
DR OMA; WSIANVI; -.
DR OrthoDB; 161881at2759; -.
DR Proteomes; UP000038009; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR039309; BT1.
DR InterPro; IPR004324; FBT.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00788; fbt; 1.
DR PANTHER; PTHR31585; FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC; 1.
DR PANTHER; PTHR31585:SF51; TRANSPORTER, PUTATIVE-RELATED; 1.
DR Pfam; PF03092; BT1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT REGION 691..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 274..304
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 692..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 77600 MW; D5EEEFE44E55DCC6 CRC64;
MHSDNHYTDA EAAVVMEESS SSTPIIRDAV AAPSATNSDY HRDYHGGVSA NEEDYVHPAS
MAIAHRAPAL FRVPFYGRSV QYLGPKVPSM LAICNFMQRG LANNLINYSK YAMFRSRFGI
SAVRYQRLAG IAGLGWSLMA FTAVFTDTFA LLQHTKRWYL VISCLLGFAF ALGFALLPAK
PSSANTGAAF MFLTVWSIAN VIILVAGQYS RLLRKSPRAG PPLVGVVYSC IMIGGIISAG
LQGPLSDRHL QHVGMYIAAV AQVMPAVFFG LNWLQEKTNA VERLEDCENN YQQALVEAQR
WDEENGLPSI PKEKGEDGSS SVVAKILFAD DDEEEHSSPY ATDAASALID DLGISAPDAP
AAASSTSRRN RVPQRRVDQV KCAVPHISRV AFGIIEVNHC VLADNWKIVL YCVVMTAGVI
AMTVVTVLGN SYDLLYCSVA VSVVCIALAF YSLPQAIAKA NVYIFLQQVF YLQLPGALDS
FYMAPEACLP AGPHFTYTFY TTVGNIIGNV GGLIGVALFT YVFSRMSYRV TMVFATIVQI
VASIFDLIIV KRWNTAIGIP DHAMYILGDQ IVYQTCYYLS YMPIVLLLSR LLPRGTECMV
MAVMSSLGNF GAALSNSVGA LVIELGWPVV ADVANNVCDF KNVPYLILVG HFACPLLIFP
LTLLLPAAKI SDDIDIDGKA IRRKVQAAAA ECGNTKASSP GPSEPVSEDQ EQRQ
//
