ID A0A0N1ILF1_LEPSE Unreviewed; 688 AA.
AC A0A0N1ILF1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 08-NOV-2023, entry version 26.
DE SubName: Full=Putative calpain-like cysteine peptidase putative cysteine peptidase Clan CA family C2 {ECO:0000313|EMBL:KPI88153.1};
GN ORFNames=ABL78_2730 {ECO:0000313|EMBL:KPI88153.1};
OS Leptomonas seymouri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leptomonas.
OX NCBI_TaxID=5684 {ECO:0000313|EMBL:KPI88153.1, ECO:0000313|Proteomes:UP000038009};
RN [1] {ECO:0000313|EMBL:KPI88153.1, ECO:0000313|Proteomes:UP000038009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30220 {ECO:0000313|EMBL:KPI88153.1,
RC ECO:0000313|Proteomes:UP000038009};
RX PubMed=26317207;
RA Kraeva N., Butenko A., Hlavacova J., Kostygov A., Myskova J., Grybchuk D.,
RA Lestinova T., Votypka J., Volf P., Opperdoes F., Flegontov P., Lukes J.,
RA Yurchenko V.;
RT "Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by
RT Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania
RT donovani.";
RL PLoS Pathog. 11:E1005127-E1005127(2015).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPI88153.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LJSK01000059; KPI88153.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N1ILF1; -.
DR EnsemblProtists; KPI88153; KPI88153; ABL78_2730.
DR VEuPathDB; TriTrypDB:Lsey_0059_0010; -.
DR OMA; NAPIMIS; -.
DR OrthoDB; 142935at2759; -.
DR Proteomes; UP000038009; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR015232; DUF1935.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR InterPro; IPR036310; Smp-1-like_sf.
DR PANTHER; PTHR47047:SF1; CYSTEINE PEPTIDASE, PUTATIVE CYSTEINE PEPTIDASE, CLAN CA, FAMILY C2, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR47047; PUTATIVE-RELATED-RELATED; 1.
DR Pfam; PF09149; DUF1935; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF101601; Smp-1-like; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 4: Predicted;
FT DOMAIN 174..499
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT ACT_SITE 417
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
FT ACT_SITE 439
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
SQ SEQUENCE 688 AA; 78249 MW; AFD2AE7F0DE81FD3 CRC64;
MTLANGKVDE FDERSVVQKK YGPSDYRYGE PVYKGEVTPC FDDGLLFRIV EKNNKNRWSF
YNDTTNTQMK VQFVFGKSSA LRALENTEME QLPDDSYRAT VVVYPMETEL FVEGETNGFT
SNIRALPLSE EYLKDMARQD FEFVKQETAT LFNSVSEKAT TDEMVNVCVK NKIKFVDFAF
PPEQKSLQIG SLMKLKVLPW ERPSMYLSDK NAKQARLFRN GVHPANLDEG DLGDSWLTGA
MAALAEFPDK IRDIFRHPES VERGQNERAC GIYRVTLNRN GWWTSVIVDD YLPVAGGRPK
FARSKGDPAE LWPSILEKAY AKAFGGYGFI VAGDPLHALQ DMSGFPCSSF DNAFVESTIN
DTFELFSHLK NYNDAGYQIV FTTPTRESIM TARGATSCGS SAQAERAYDK ANLLLGHTYS
VIRVGYFEEY GLRLMHLRNP WSQASSDWNG PWNKRDKNWD KYTVVADYFN FDSSDDGTFF
MEWTDVQDYF VGCGVCFIQH PMYDYRIRGT FFQNVPTTCL EISVARPTVI NLILSQEDKR
GTDKPENAPI MISVAHGMGA MSPMRVDMNS GFDNDHPSPE YTFLQSRDVS MFYEFTPENS
PYLVVPRTMS QFAKLPYTLG LLCPHEIGKT NSEVRVAFRA LAPENRIFDN FQKFNCETVA
TETEFQAKGT KQFFPDIYVG TIVQTSDD
//
