ID   A0A0N1NHW8_9ACTN        Unreviewed;       320 AA.
AC   A0A0N1NHW8;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Transcriptional regulator, TetR family {ECO:0000313|EMBL:KPI14996.1};
GN   ORFNames=OK006_2869 {ECO:0000313|EMBL:KPI14996.1};
OS   Actinobacteria bacterium OK006.
OC   Bacteria; Actinomycetota; Actinomycetes.
OX   NCBI_TaxID=1592326 {ECO:0000313|EMBL:KPI14996.1, ECO:0000313|Proteomes:UP000037912};
RN   [1] {ECO:0000313|EMBL:KPI14996.1, ECO:0000313|Proteomes:UP000037912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OK006 {ECO:0000313|EMBL:KPI14996.1,
RC   ECO:0000313|Proteomes:UP000037912};
RA   Brown S.D., Utturkar S.M., Klingeman D.M., Pelletier D.;
RT   "Draft genome sequences for four Actinobacteria strains OK006 OK074 OV450
RT   and OV320.";
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPI14996.1}.
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DR   EMBL; LJCU01000087; KPI14996.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N1NHW8; -.
DR   PATRIC; fig|1592326.3.peg.3070; -.
DR   Proteomes; UP000037912; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR   PANTHER; PTHR30055:SF226; HTH-TYPE TRANSCRIPTIONAL REPRESSOR RV1474C; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          80..140
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50977"
FT   DNA_BIND        103..122
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   320 AA;  34773 MW;  8FA8F394B944BE1C CRC64;
     MPAAERPGDR LPDTARWGGL LGPAGSPPPV EGGGFPGHAR SPAQMQYVRV MSQPAKSSRT
     PATPDAPESA AGSRAAAQRL KMRRELAAAA MELFATKGYE ATTVDEIAAR AGVARRTFFR
     HFRSKEEAIF PDHDDTLIRA EAVLNAAPAH EHPLDTVCRG IKEVMTMYAA QPEISVSRYK
     LTREVPTLRE AEIASVARYE RLFTRYLLGH FDEHAHDDDA NDDPLLAEVA ASAVVTAHNH
     VLRRWLRAGG QGDVEAQLDH AFSIVRKTFG TGIGAGRETT PRTAPASAFT EGDVLVTVAR
     VDAPLDQVMR TIEQALRERA
//